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乳头状瘤病毒：在皮肤癌免疫中从敌人到朋友

IF 48.8 1区 医学 Q1 CELL BIOLOGY
Cancer Cell Pub Date : 2025-01-02 DOI:10.1016/j.ccell.2024.12.005
Marta Lebrusant-Fernandez, James L. Reading
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引用次数: 0

摘要

在这一期的《癌细胞》杂志上，Son等人强调了皮肤β-乳头瘤病毒在防止皮肤癌变中的意想不到的作用。T细胞对皮肤乳头瘤病毒的免疫阻止了p53突变克隆在紫外线（UV）辐射受损的皮肤中的扩张，从而防止皮肤癌的发展。
本文章由计算机程序翻译，如有差异，请以英文原文为准。
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Beta papillomaviruses: From foe to friend in skin cancer immunity
In this issue of Cancer Cell, Son et al. highlight an unexpected role for skin β-papillomaviruses in the protection against skin carcinogenesis. T cell immunity to skin papillomaviruses blocks the expansion of p53 mutant clones in ultraviolet (UV) radiation-damaged skin, preventing the development of skin cancer.
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来源期刊
Cancer Cell
Cancer Cell 医学-肿瘤学
CiteScore
55.20
自引率
1.20%
发文量
179
审稿时长
4-8 weeks
期刊介绍： Cancer Cell is a journal that focuses on promoting major advances in cancer research and oncology. The primary criteria for considering manuscripts are as follows: Major advances: Manuscripts should provide significant advancements in answering important questions related to naturally occurring cancers. Translational research: The journal welcomes translational research, which involves the application of basic scientific findings to human health and clinical practice. Clinical investigations: Cancer Cell is interested in publishing clinical investigations that contribute to establishing new paradigms in the treatment, diagnosis, or prevention of cancers. Insights into cancer biology: The journal values clinical investigations that provide important insights into cancer biology beyond what has been revealed by preclinical studies. Mechanism-based proof-of-principle studies: Cancer Cell encourages the publication of mechanism-based proof-of-principle clinical studies, which demonstrate the feasibility of a specific therapeutic approach or diagnostic test.
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