探索长非编码 RNA 在预测乙型肝炎患者预后中的作用。

Q2 Medicine

Asian Pacific Journal of Cancer Prevention Pub Date : 2024-12-01 DOI:10.31557/APJCP.2024.25.12.4313

Hilal Basyegit, Bengu Gireniz Tatar, Sukran Kose, Cumhur Gunduz, Besra Ozmen Yelken, Sunde Yilmaz Susluer

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引用次数: 0

摘要

背景：乙型肝炎是世界范围内一个重要的公共卫生问题。长链非编码rna （lncRNAs）在生物学机制中起着关键作用。lncrna在乙型肝炎中的作用尚不完全清楚。本研究旨在探索某些lncrna作为乙型肝炎诊断和预后标志物的潜力，以及它们区分临床疾病亚组的能力。方法：对204例诊断为乙型肝炎患者的血浆样本进行仔细检查，以确定是否存在特定的lncrna，重点关注文献中已知的与乙型肝炎相关的lncrna。本研究分析了14种lncrna在慢性、康复和无活性HBsAg携带者3个亚组中的基因表达水平，并与健康对照组进行了比较。结果：在所有患者中RN7SL1和α -280基因的下调提示潜在的诊断lncrna。ZFHX2-AS1在所有亚组中表达均较低，而SRA1在康复的乙型肝炎患者中表达较高，提示其是一种描述性标志物。DLG2-AS2在慢性乙型肝炎中表达升高，而在其他组中表达降低。ZFHX2-AS1、RN7SL1、PCAT-1、PCA3、SRA1和Alpha-280的表达水平已被确定为诊断乙型肝炎和区分其临床亚群的重要生物标志物。研究表明，乙肝疾病与DLG2-AS2、HOTTIP、HOTAIRM1、HOXA11-AS、NOS2P3、LINC02665、MEG9和RNY5 lncRNAs的基因表达密切相关。

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Exploring the Role of Long Non-Coding RNAs in Predicting Outcomes for Hepatitis B Patients.

Background: Hepatitis B is a significant public health issue worldwide. Long noncoding RNAs (lncRNAs) are pivotal in biological mechanisms. The involvement of lncRNAs in hepatitis Hepatitis B remains incompletely understood. This study sought to explore the potential of certain lncRNAs as diagnostic and prognostic markers in hepatitis B, and their ability to differentiate between clinical disease subgroups.

Methods: Plasma samples from 204 individuals diagnosed with hepatitis B were meticulously examined for the presence of specific lncRNAs, focusing on those known to be associated with hepatitis B as indicated in the literature. In this study, gene expression levels of 14 lncRNAs were analyzed in three subgroups (chronic, recovered and inactive HBsAg carriers) and compared with those in the healthy control group.

Results: The downregulation of the RN7SL1 and Alpha-280 genes in all patients indicates potential diagnostic lncRNAs. ZFHX2-AS1 expression was consistently lower in all subgroups, while SRA1 showed high expression in recovered hepatitis B patients, indicating that it is a descriptive marker. DLG2-AS2 expression increased in the chronic hepatitis B but decreased in the other groups.

Conclusions: These findings reveal the prognostic importance of lncRNAs in hepatitis B. The expression levels of ZFHX2-AS1, RN7SL1, PCAT-1, PCA3, SRA1 and Alpha-280 have been identified as crucial biomarkers for the diagnosis of hepatitis B and for distinguishing between its clinical subgroups. A strong association between hepatitis B disease and the gene expression of the DLG2-AS2, HOTTIP, HOTAIRM1, HOXA11-AS, NOS2P3, LINC02665, MEG9, and RNY5 lncRNAs has been suggested.

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来源期刊

Asian Pacific Journal of Cancer Prevention 医学-肿瘤学

CiteScore

2.80

自引率

0.00%

发文量

779

审稿时长

3 months

期刊介绍： Cancer is a very complex disease. While many aspects of carcinoge-nesis and oncogenesis are known, cancer control and prevention at the community level is however still in its infancy. Much more work needs to be done and many more steps need to be taken before effective strategies are developed. The multidisciplinary approaches and efforts to understand and control cancer in an effective and efficient manner, require highly trained scientists in all branches of the cancer sciences, from cellular and molecular aspects to patient care and palliation. The Asia Pacific Organization for Cancer Prevention (APOCP) and its official publication, the Asia Pacific Journal of Cancer Prevention (APJCP), have served the community of cancer scientists very well and intends to continue to serve in this capacity to the best of its abilities. One of the objectives of the APOCP is to provide all relevant and current scientific information on the whole spectrum of cancer sciences. They aim to do this by providing a forum for communication and propagation of original and innovative research findings that have relevance to understanding the etiology, progression, treatment, and survival of patients, through their journal. The APJCP with its distinguished, diverse, and Asia-wide team of editors, reviewers, and readers, ensure the highest standards of research communication within the cancer sciences community across Asia as well as globally. The APJCP publishes original research results under the following categories: -Epidemiology, detection and screening. -Cellular research and bio-markers. -Identification of bio-targets and agents with novel mechanisms of action. -Optimal clinical use of existing anti-cancer agents, including combination therapies. -Radiation and surgery. -Palliative care. -Patient adherence, quality of life, satisfaction. -Health economic evaluations.