三袋法乙酰半胱氨酸与两袋法乙酰半胱氨酸治疗对乙酰氨基酚毒性的比较:最新的系统综述和荟萃分析。

IF 2.9 Q2 MEDICINE, RESEARCH & EXPERIMENTAL
Mohammed Alrashed, Abdulrahman Alyousef, Hisham A Badreldin, Khalid Bin Saleh, Shmeylan Al Harbi, Abdulkareem M Albekairy, Abrar Alghamdi, Amal Al-Nahdi, Dhay Alonazi, Mohammed Alnuhait, Abdullah Alshammari, Tariq Alqahtani
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引用次数: 0

摘要

背景:对乙酰氨基酚在按照推荐指南使用时通常被认为是安全的。过量食用可导致严重的肝损伤,在危急情况下甚至可能导致死亡。为了减少对乙酰氨基酚过量的影响,n -乙酰半胱氨酸(NAC)已被确定为预防肝损害的首选干预措施。目的:本更新的系统综述和荟萃分析的目的是评估两袋n-乙酰半胱氨酸(NAC)给药方案与传统三袋方案在治疗对乙酰氨基酚诱导的肝毒性方面的潜在益处。方法:本系统评价按照系统评价和荟萃分析指南的首选报告项目进行。研究小组利用PubMed和Cochrane数据库,对从这些数据库建立到2024年1月的相关文献进行了彻底而全面的搜索。结果:纳入9项研究。与三袋方法相比,两袋NAC的总体使用与较低的过敏反应和胃肠道症状相关。两治疗组肝毒性消退率相同。结论:两袋NAC方案是一种安全有效的治疗对乙酰氨基酚毒性的方法。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Comparison of Three-Bag Method Acetylcysteine Versus Two-Bag Method Acetylcysteine for the Treatment of Acetaminophen Toxicity: An Updated Systematic Review and Meta-Analysis.

Background: Acetaminophen is generally considered safe when used according to the recommended guidelines. Consumption in excessive doses can lead to severe liver damage and, in critical cases, may even result in death. To reduce the effects of acetaminophen overdose, N-acetylcysteine (NAC) has been established as the preferred intervention to prevent liver damage.

Objectives: The purpose of this updated systematic review and meta-analysis is to evaluate the potential benefits of a two-bag N-acetylcysteine (NAC) dosing regimen compared to the traditional three-bag protocol in the treatment of acetaminophen-induced liver toxicity.

Methods: This systematic review was conducted in accordance with the Preferred Reporting Items for Systematic Reviews and Meta-Analyses guidelines. The research team utilized the PubMed and Cochrane databases to perform a thorough and comprehensive search of the relevant literature from the inception of these databases up until January 2024.

Results: Nine studies were included. The overall use of two-bag NAC was associated with lower anaphylactic reactions and gastrointestinal symptoms compared to the three-bag method. The rate of liver toxicity resolution was the same between the two treatment groups.

Conclusions: The two-bag NAC regimen can be considered a safe and effective method for managing acetaminophen toxicity.

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