ABO、FUT2与慢性胰腺炎之间的关系：一项针对多个队列和公共生物库的综合荟萃分析

IF 2.8 2区医学 Q2 GASTROENTEROLOGY & HEPATOLOGY

Pancreatology Pub Date : 2025-02-01 DOI:10.1016/j.pan.2024.12.016

Zeng-Kan Du , Yuan-Chen Wang , Ya-Hui Wang , Xiao-Yu Li , Yi-Zhou Zheng , Di Wu , Wei-Ming Qu , Zhuan Liao , Wen-Bin Zou

{"title":"ABO、FUT2与慢性胰腺炎之间的关系：一项针对多个队列和公共生物库的综合荟萃分析","authors":"Zeng-Kan Du , Yuan-Chen Wang , Ya-Hui Wang , Xiao-Yu Li , Yi-Zhou Zheng , Di Wu , Wei-Ming Qu , Zhuan Liao , Wen-Bin Zou","doi":"10.1016/j.pan.2024.12.016","DOIUrl":null,"url":null,"abstract":"<div><h3>Objectives</h3><div>Associations of ABO blood group specifying transferases A/B (<em>ABO</em>) and fucosyltransferase 2 (<em>FUT2</em>) with CP remain inconclusive. We aimed to comprehensively investigate the associations by Chinese sequencing cohorts and external cohorts.</div></div><div><h3>Methods</h3><div>First, we analyzed the distributions of ABO blood groups and FUT2 status, along with lead single nucleotide polymorphisms (SNPs) at <em>ABO</em> (rs8176693 C/T) and <em>FUT2</em> (rs632111 A/G) gene loci in Chinese low-coverage whole-genome sequencing discovery cohort. Subsequently, we investigated the associations of CP with <em>ABO</em> and <em>FUT2</em> SNPs in Chinese whole-exome sequencing validation cohort and three public biobanks (FinnGen, UK Biobank, and BioBank Japan). Finally, comprehensive meta-analysis was performed by integrating data from two Chinese cohorts, reported cohorts and public biobanks.</div></div><div><h3>Results</h3><div>Firstly, in Chinese discovery cohort, the distribution of blood types in CP patients showed no significant difference compared to healthy controls, and similar results were observed in subgroup analyses and in meta-analysis with the reported cohorts. Secondly, results indicated no association between rs8176693 or rs632111 and CP in Chinese cohorts and meta-analysis of three biobanks, though <em>ABO</em> SNP was found to be significantly associated with CP in UK Biobank (odds ratio [OR] = 1.27, <em>P</em> = 0.04). Finally, no association was observed between rs8176693 (OR = 1.03, <em>P</em> = 0.29) or rs632111 (OR = 1.04, <em>P</em> = 0.10) and CP in comprehensive meta-analysis.</div></div><div><h3>Conclusions</h3><div>No association was found between lead SNPs of <em>ABO</em> or <em>FUT2</em> and CP in meta-analysis, nor was there an association between ABO blood group or FUT2 secretor status and CP in Chinese cohort. <em>ABO</em> and <em>FUT2</em> might play limited role in CP development.</div></div>","PeriodicalId":19976,"journal":{"name":"Pancreatology","volume":"25 1","pages":"Pages 58-64"},"PeriodicalIF":2.8000,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Associations between ABO, FUT2 and chronic pancreatitis: A comprehensive meta-analysis of multiple cohorts and public biobanks\",\"authors\":\"Zeng-Kan Du , Yuan-Chen Wang , Ya-Hui Wang , Xiao-Yu Li , Yi-Zhou Zheng , Di Wu , Wei-Ming Qu , Zhuan Liao , Wen-Bin Zou\",\"doi\":\"10.1016/j.pan.2024.12.016\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><h3>Objectives</h3><div>Associations of ABO blood group specifying transferases A/B (<em>ABO</em>) and fucosyltransferase 2 (<em>FUT2</em>) with CP remain inconclusive. We aimed to comprehensively investigate the associations by Chinese sequencing cohorts and external cohorts.</div></div><div><h3>Methods</h3><div>First, we analyzed the distributions of ABO blood groups and FUT2 status, along with lead single nucleotide polymorphisms (SNPs) at <em>ABO</em> (rs8176693 C/T) and <em>FUT2</em> (rs632111 A/G) gene loci in Chinese low-coverage whole-genome sequencing discovery cohort. Subsequently, we investigated the associations of CP with <em>ABO</em> and <em>FUT2</em> SNPs in Chinese whole-exome sequencing validation cohort and three public biobanks (FinnGen, UK Biobank, and BioBank Japan). Finally, comprehensive meta-analysis was performed by integrating data from two Chinese cohorts, reported cohorts and public biobanks.</div></div><div><h3>Results</h3><div>Firstly, in Chinese discovery cohort, the distribution of blood types in CP patients showed no significant difference compared to healthy controls, and similar results were observed in subgroup analyses and in meta-analysis with the reported cohorts. Secondly, results indicated no association between rs8176693 or rs632111 and CP in Chinese cohorts and meta-analysis of three biobanks, though <em>ABO</em> SNP was found to be significantly associated with CP in UK Biobank (odds ratio [OR] = 1.27, <em>P</em> = 0.04). Finally, no association was observed between rs8176693 (OR = 1.03, <em>P</em> = 0.29) or rs632111 (OR = 1.04, <em>P</em> = 0.10) and CP in comprehensive meta-analysis.</div></div><div><h3>Conclusions</h3><div>No association was found between lead SNPs of <em>ABO</em> or <em>FUT2</em> and CP in meta-analysis, nor was there an association between ABO blood group or FUT2 secretor status and CP in Chinese cohort. <em>ABO</em> and <em>FUT2</em> might play limited role in CP development.</div></div>\",\"PeriodicalId\":19976,\"journal\":{\"name\":\"Pancreatology\",\"volume\":\"25 1\",\"pages\":\"Pages 58-64\"},\"PeriodicalIF\":2.8000,\"publicationDate\":\"2025-02-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Pancreatology\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S1424390324008445\",\"RegionNum\":2,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"GASTROENTEROLOGY & HEPATOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Pancreatology","FirstCategoryId":"3","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S1424390324008445","RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"GASTROENTEROLOGY & HEPATOLOGY","Score":null,"Total":0}

引用次数: 0

摘要

目的：ABO血型指定转移酶A/B （ABO）和聚焦转移酶2 （FUT2）与CP的关系仍不确定。我们的目的是通过中国测序队列和外部队列来全面调查这种关联。方法：首先，我们分析了中国低覆盖率全基因组测序发现队列中ABO血型分布和FUT2状态，以及ABO （rs8176693 C/T）和FUT2 （rs632111 A/G）基因位点的先导单核苷酸多态性（snp）。随后，我们在中国全外显子组测序验证队列和三个公共生物银行（FinnGen， UK Biobank和Biobank Japan）中研究了CP与ABO和FUT2 snp的关系。结果：首先，在中国发现队列中，CP患者的血型分布与健康对照无显著差异，在亚组分析和meta分析中，与已报道队列的结果相似。其次，结果显示rs8176693或rs632111与中国队列和三个生物库的荟萃分析之间没有相关性，尽管ABO SNP与英国生物库的CP显著相关（优势比[or] = 1.27, P = 0.04）。最后，在综合meta分析中，rs8176693 （OR = 1.03, P = 0.29）或rs632111 （OR = 1.04, P = 0.10）与CP无相关性。结论：荟萃分析未发现ABO或FUT2的先导snp与CP之间存在关联，中国队列中ABO血型或FUT2分泌状态与CP之间也没有关联。ABO和FUT2可能在CP的发展中发挥有限的作用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

查看原文本刊更多论文

Associations between ABO, FUT2 and chronic pancreatitis: A comprehensive meta-analysis of multiple cohorts and public biobanks

Objectives

Associations of ABO blood group specifying transferases A/B (ABO) and fucosyltransferase 2 (FUT2) with CP remain inconclusive. We aimed to comprehensively investigate the associations by Chinese sequencing cohorts and external cohorts.

Methods

First, we analyzed the distributions of ABO blood groups and FUT2 status, along with lead single nucleotide polymorphisms (SNPs) at ABO (rs8176693 C/T) and FUT2 (rs632111 A/G) gene loci in Chinese low-coverage whole-genome sequencing discovery cohort. Subsequently, we investigated the associations of CP with ABO and FUT2 SNPs in Chinese whole-exome sequencing validation cohort and three public biobanks (FinnGen, UK Biobank, and BioBank Japan). Finally, comprehensive meta-analysis was performed by integrating data from two Chinese cohorts, reported cohorts and public biobanks.

Results

Firstly, in Chinese discovery cohort, the distribution of blood types in CP patients showed no significant difference compared to healthy controls, and similar results were observed in subgroup analyses and in meta-analysis with the reported cohorts. Secondly, results indicated no association between rs8176693 or rs632111 and CP in Chinese cohorts and meta-analysis of three biobanks, though ABO SNP was found to be significantly associated with CP in UK Biobank (odds ratio [OR] = 1.27, P = 0.04). Finally, no association was observed between rs8176693 (OR = 1.03, P = 0.29) or rs632111 (OR = 1.04, P = 0.10) and CP in comprehensive meta-analysis.

Conclusions

No association was found between lead SNPs of ABO or FUT2 and CP in meta-analysis, nor was there an association between ABO blood group or FUT2 secretor status and CP in Chinese cohort. ABO and FUT2 might play limited role in CP development.

求助全文

通过发布文献求助，成功后即可免费获取论文全文。去求助

来源期刊

Pancreatology 医学-胃肠肝病学

CiteScore

7.20

自引率

5.60%

发文量

194

审稿时长

44 days

期刊介绍： Pancreatology is the official journal of the International Association of Pancreatology (IAP), the European Pancreatic Club (EPC) and several national societies and study groups around the world. Dedicated to the understanding and treatment of exocrine as well as endocrine pancreatic disease, this multidisciplinary periodical publishes original basic, translational and clinical pancreatic research from a range of fields including gastroenterology, oncology, surgery, pharmacology, cellular and molecular biology as well as endocrinology, immunology and epidemiology. Readers can expect to gain new insights into pancreatic physiology and into the pathogenesis, diagnosis, therapeutic approaches and prognosis of pancreatic diseases. The journal features original articles, case reports, consensus guidelines and topical, cutting edge reviews, thus representing a source of valuable, novel information for clinical and basic researchers alike.