α -蒎烯预处理对雄性大鼠肾缺血再灌注损伤的保护作用。

IF 0.8 4区医学 Q4 UROLOGY & NEPHROLOGY

Iranian journal of kidney diseases Pub Date : 2024-12-19 DOI:10.52547/j3msd881

引用次数: 0

摘要

器官移植缺血再灌注可导致缺血再灌注（I-R）损伤，这与氧化应激和炎症反应有关。α -蒎烯是一种有机萜烯，具有众所周知的抗氧化、抗炎和抗细胞凋亡的特性。本研究探讨了α -蒎烯对肾i - r诱导的肾功能障碍、氧化和炎症状态、细胞凋亡和组织病理学改变的预防作用。方法：42只体重200 ~ 250 gr的成年雄性Wistar大鼠分为6组（n = 7）：对照组、右肾切除组、缺血-再灌注组（缺血45 min、再灌注24 h）、I-R + 3种不同剂量的α -蒎烯（2.5、5、10 mg/kg） 24 h和缺血诱导前灌胃组。24小时后，收集尿液、血清和剩余肾脏进行生化和组织分析。结果：肾I-R引起肾损伤，表现为肌酐清除率显著降低、氧化应激诱导、炎症细胞因子增加和组织病理学损伤。α -蒎烯通过恢复对照组的变化显著改善了损伤。有效剂量（2.5 mg/kg）的α -蒎烯可降低Bax、Bcl-2、TNF-α和il - 1β的水平，并有助于肾I-R后组织损伤的再生。结论：α -蒎烯具有抗氧化、抗炎和抗细胞凋亡的作用，可减少并发症的发生。提示其可作为减少肾移植术后肾脏并发症的预处理。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Iranian journal of kidney diseases UROLOGY & NEPHROLOGY-

CiteScore

2.50

自引率

0.00%

发文量

审稿时长

6-12 weeks

期刊介绍： The Iranian Journal of Kidney Diseases (IJKD), a peer-reviewed journal in English, is the official publication of the Iranian Society of Nephrology. The aim of the IJKD is the worldwide reflection of the knowledge produced by the scientists and clinicians in nephrology. Published quarterly, the IJKD provides a new platform for advancement of the field. The journal’s objective is to serve as a focal point for debates and exchange of knowledge and experience among researchers in a global context. Original papers, case reports, and invited reviews on all aspects of the kidney diseases, hypertension, dialysis, and transplantation will be covered by the IJKD. Research on the basic science, clinical practice, and socio-economics of renal health are all welcomed by the editors of the journal.