肾脏疾病的细胞治疗:推进肾脏再生的治疗。

IF 4.6 2区 生物学 Q2 CELL BIOLOGY
Frontiers in Cell and Developmental Biology Pub Date : 2024-12-11 eCollection Date: 2024-01-01 DOI:10.3389/fcell.2024.1505601
Amankeldi A Salybekov, Aiman Kinzhebay, Shuzo Kobayashi
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引用次数: 0

摘要

肾脏疾病,包括急性肾损伤(AKI)和慢性肾脏疾病(CKD),是一个重大的全球健康挑战,其高发病率和死亡率是由糖尿病和高血压等风险因素的患病率上升所驱动的。目前的治疗策略往往是有限的,促使探索先进的细胞疗法作为潜在的解决方案。本文综述了肾脏疾病细胞治疗的现状,追踪了从临床前研究到临床应用的进展。最近的研究强调,基于细胞的干预通过旁分泌信号、免疫调节和直接组织整合等机制提供肾脏保护特性,证明了在AKI和CKD情况下的潜力。尽管取得了令人鼓舞的结果,但在优化细胞治疗方案方面仍然存在挑战,包括细胞来源、递送方法和长期结果。最后,本文综述了增强细胞功能、优化剂量和改进给药技术以改善肾脏疾病治疗的临床结果的努力。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Cell therapy in kidney diseases: advancing treatments for renal regeneration.

Kidney diseases, including acute kidney injury (AKI) and chronic kidney disease (CKD), pose a significant global health challenge, with high morbidity and mortality rates driven by rising prevalence of risk factors such as diabetes and hypertension. Current therapeutic strategies are often limited, prompting the exploration of advanced cell therapies as potential solutions. This review provides a comprehensive overview of the state of cell therapies in kidney disease, tracing the progression from preclinical studies to clinical applications. Recent studies highlited that cell-based interventions offer kidney-protective properties through mechanisms such as paracrine signaling, immune modulation, and direct tissue integration, demonstrating potential in both AKI and CKD settings. Despite promising results, challenges remain in optimizing cell therapy protocols, including cell sourcing, delivery methods, and long-term outcomes. Finally, the review addresses on efforts to enhance cell function, optimize dosing, and refine delivery techniques to improve clinical outcomes in kidney disease management.

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来源期刊
Frontiers in Cell and Developmental Biology
Frontiers in Cell and Developmental Biology Biochemistry, Genetics and Molecular Biology-Cell Biology
CiteScore
9.70
自引率
3.60%
发文量
2531
审稿时长
12 weeks
期刊介绍: Frontiers in Cell and Developmental Biology is a broad-scope, interdisciplinary open-access journal, focusing on the fundamental processes of life, led by Prof Amanda Fisher and supported by a geographically diverse, high-quality editorial board. The journal welcomes submissions on a wide spectrum of cell and developmental biology, covering intracellular and extracellular dynamics, with sections focusing on signaling, adhesion, migration, cell death and survival and membrane trafficking. Additionally, the journal offers sections dedicated to the cutting edge of fundamental and translational research in molecular medicine and stem cell biology. With a collaborative, rigorous and transparent peer-review, the journal produces the highest scientific quality in both fundamental and applied research, and advanced article level metrics measure the real-time impact and influence of each publication.
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