MRSA治疗的进展：小檗碱在加强抗生素治疗中的作用。

IF 4 2区生物学 Q2 MICROBIOLOGY

BMC Microbiology Pub Date : 2024-12-27 DOI:10.1186/s12866-024-03692-9

Fangfang Zhou, Xuemei Gu, Wei Wang, Ming Lin, Lei Wang

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引用次数: 0

摘要

背景：耐甲氧西林金黄色葡萄球菌（MRSA）是一个重大的公共卫生问题。本研究探讨了植物生物碱小檗碱（berberine， BBR）对MRSA的抗菌特性和作用机制，评价了其增强抗生素治疗的潜力。结果：小檗碱对50株临床MRSA菌株仅表现出不同但显著的抑制作用。当与抗生素联合使用时，在50株MRSA中只有6株与阿米卡星有协同作用。BBR破坏MRSA细胞壁完整性，导致细胞内容物渗漏。网络药理学分析显示，BBR靶向细菌生存所必需的多种途径。结论：小檗碱具有较强的抗MRSA活性，并能与传统抗生素协同作用。小檗碱对细胞壁完整性和细菌存活途径的影响突出了其作为MRSA治疗辅助疗法的潜力。

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Advancements in MRSA treatment: the role of berberine in enhancing antibiotic therapy.

Background: Methicillin-resistant Staphylococcus aureus (MRSA) is a significant public health problem. This study investigated the antimicrobial properties and mechanisms of berberine (BBR), a plant alkaloid, against MRSA, evaluating its potential to enhance antibiotic therapy.

Results: Berberine only demonstrated variable but significant inhibitory effects on 50 clinical MRSA strains. When combined with antibiotics, synergistic effects were observed only with amikacin in 6 of the 50 MRSA strains. BBR disrupted MRSA cell wall integrity, leading to leakage of cellular contents. Network pharmacology analysis revealed that BBR targets multiple pathways essential for bacterial survival.

Conclusion: The study confirmed the potent antimicrobial activity of berberine against MRSA and its capability to act synergistically with traditional antibiotics. Berberine's impact on cell wall integrity and bacterial survival pathways highlights its potential as an adjunct therapy in MRSA treatment.

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来源期刊

BMC Microbiology 生物-微生物学

CiteScore

7.20

自引率

0.00%

发文量

280

审稿时长

3 months

期刊介绍： BMC Microbiology is an open access, peer-reviewed journal that considers articles on analytical and functional studies of prokaryotic and eukaryotic microorganisms, viruses and small parasites, as well as host and therapeutic responses to them and their interaction with the environment.