肥胖相关肾脏疾病研究进展

Q4 Medicine

中国医学科学院学报 Pub Date : 2024-12-27 DOI:10.3881/j.issn.1000-503X.16098

Rui-Feng Yang, Wen Wu, Peng Zhang

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引用次数: 0

摘要

肥胖相关性肾病（obesity-associated kidney disease， OAKD）的发病机制涉及肾素-血管紧张素-醛固酮系统的过度激活、胰岛素抵抗、慢性炎症、脂质代谢紊乱和肠道微生态失衡等多个方面。OAKD的治疗策略侧重于生活方式调整、药物治疗、减肥手术和粪便微生物群移植。更深入地了解OAKD的危害及其发病机制，将有助于在未来制定个性化和精准的预防、诊断和治疗策略。

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Research Progress on Obesity-Associated Kidney Diseases.

The pathogenesis of obesity-associated kidney disease (OAKD) involves many aspects,including the overactivation of the renin-angiotensin-aldosterone system,insulin resistance,chronic inflammation,disorder of lipid metabolism and imbalance of gut microecology.Treatment strategies for OAKD focus on lifestyle adjustments,pharmacotherapy,bariatric surgery,and fecal microbiota transplantation.A deeper understanding of the hazards of OAKD and its pathogenesis will contribute to the development of personalized and precise strategies for prevention,diagnosis and treatment of OAKD in the future.

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来源期刊

中国医学科学院学报 Medicine-Medicine (all)

CiteScore

0.60

自引率

0.00%

发文量

6813

期刊介绍： Acta Academiae Medicinae Sinicae was founded in February 1979. It is a comprehensive medical academic journal published in China and abroad, supervised by the Ministry of Health of the People's Republic of China and sponsored by the Chinese Academy of Medical Sciences and Peking Union Medical College. The journal mainly reports the latest research results, work progress and dynamics in the fields of basic medicine, clinical medicine, pharmacy, preventive medicine, biomedicine, medical teaching and research, aiming to promote the exchange of medical information and improve the academic level of medicine. At present, the journal has been included in 10 famous foreign retrieval systems and their databases [Medline (PubMed online version), Elsevier, EMBASE, CA, WPRIM, ExtraMED, IC, JST, UPD and EBSCO-ASP]; and has been included in important domestic retrieval systems and databases [China Science Citation Database (Documentation and Information Center of the Chinese Academy of Sciences), China Core Journals Overview (Peking University Library), China Science and Technology Paper Statistical Source Database (China Science and Technology Core Journals) (China Institute of Scientific and Technological Information), China Science and Technology Journal Paper and Citation Database (China Institute of Scientific and Technological Information)].