{"title":"双金属ZnO/CeO2纳米颗粒的生物合成及体外细胞毒性能研究","authors":"Khadijeh Hamidian, Mina Sarani","doi":"10.1007/s13538-024-01685-7","DOIUrl":null,"url":null,"abstract":"<div><p>Our research explored an environmentally friendly approach for the synthesis of bimetallic zinc oxide-cerium oxide nanoparticles (ZC NP) through the utilization of <i>Salvadora persica</i> extract. We characterized the physicochemical properties of the synthesized nanoparticles using PXRD, Raman spectroscopy, FESEM, and EDX analyses. As a result, both main peaks of zinc oxide and cerium oxide NP appeared in the PXRD graph, which indicated the formation of bimetallic NP. Spherical morphology showed in the FESEM image which particles have a size of about 30–40 nm. The analysis of hemocompatibility indicated that the NP does not appreciably affect the integrity of erythrocytes at concentrations nearing 2000 µg mL<sup>−1</sup>. The toxicity function of synthesized sample on human colon cancer (HT-29) and fibroblast (NIH/3T3) cells was considered through the results of MTT trial. The outcomes of synthesized NP displayed significant cytotoxic effects against HT-29 cells at 20.73 μg mL<sup>−1</sup> concentration as its IC50, while it was non-toxic on NIH-3T3 cells. Therefore, we suggest the applicability of our product in therapeutic applications such as drug delivery as well as industrial implementations.</p></div>","PeriodicalId":499,"journal":{"name":"Brazilian Journal of Physics","volume":"55 1","pages":""},"PeriodicalIF":1.5000,"publicationDate":"2024-12-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Biosynthesis and In Vitro Cytotoxic Performance of Bimetallic ZnO/CeO2 Nanoparticles\",\"authors\":\"Khadijeh Hamidian, Mina Sarani\",\"doi\":\"10.1007/s13538-024-01685-7\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><p>Our research explored an environmentally friendly approach for the synthesis of bimetallic zinc oxide-cerium oxide nanoparticles (ZC NP) through the utilization of <i>Salvadora persica</i> extract. We characterized the physicochemical properties of the synthesized nanoparticles using PXRD, Raman spectroscopy, FESEM, and EDX analyses. As a result, both main peaks of zinc oxide and cerium oxide NP appeared in the PXRD graph, which indicated the formation of bimetallic NP. Spherical morphology showed in the FESEM image which particles have a size of about 30–40 nm. The analysis of hemocompatibility indicated that the NP does not appreciably affect the integrity of erythrocytes at concentrations nearing 2000 µg mL<sup>−1</sup>. The toxicity function of synthesized sample on human colon cancer (HT-29) and fibroblast (NIH/3T3) cells was considered through the results of MTT trial. The outcomes of synthesized NP displayed significant cytotoxic effects against HT-29 cells at 20.73 μg mL<sup>−1</sup> concentration as its IC50, while it was non-toxic on NIH-3T3 cells. Therefore, we suggest the applicability of our product in therapeutic applications such as drug delivery as well as industrial implementations.</p></div>\",\"PeriodicalId\":499,\"journal\":{\"name\":\"Brazilian Journal of Physics\",\"volume\":\"55 1\",\"pages\":\"\"},\"PeriodicalIF\":1.5000,\"publicationDate\":\"2024-12-28\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Brazilian Journal of Physics\",\"FirstCategoryId\":\"101\",\"ListUrlMain\":\"https://link.springer.com/article/10.1007/s13538-024-01685-7\",\"RegionNum\":4,\"RegionCategory\":\"物理与天体物理\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"PHYSICS, MULTIDISCIPLINARY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Brazilian Journal of Physics","FirstCategoryId":"101","ListUrlMain":"https://link.springer.com/article/10.1007/s13538-024-01685-7","RegionNum":4,"RegionCategory":"物理与天体物理","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"PHYSICS, MULTIDISCIPLINARY","Score":null,"Total":0}
Biosynthesis and In Vitro Cytotoxic Performance of Bimetallic ZnO/CeO2 Nanoparticles
Our research explored an environmentally friendly approach for the synthesis of bimetallic zinc oxide-cerium oxide nanoparticles (ZC NP) through the utilization of Salvadora persica extract. We characterized the physicochemical properties of the synthesized nanoparticles using PXRD, Raman spectroscopy, FESEM, and EDX analyses. As a result, both main peaks of zinc oxide and cerium oxide NP appeared in the PXRD graph, which indicated the formation of bimetallic NP. Spherical morphology showed in the FESEM image which particles have a size of about 30–40 nm. The analysis of hemocompatibility indicated that the NP does not appreciably affect the integrity of erythrocytes at concentrations nearing 2000 µg mL−1. The toxicity function of synthesized sample on human colon cancer (HT-29) and fibroblast (NIH/3T3) cells was considered through the results of MTT trial. The outcomes of synthesized NP displayed significant cytotoxic effects against HT-29 cells at 20.73 μg mL−1 concentration as its IC50, while it was non-toxic on NIH-3T3 cells. Therefore, we suggest the applicability of our product in therapeutic applications such as drug delivery as well as industrial implementations.
期刊介绍：
The Brazilian Journal of Physics is a peer-reviewed international journal published by the Brazilian Physical Society (SBF). The journal publishes new and original research results from all areas of physics, obtained in Brazil and from anywhere else in the world. Contents include theoretical, practical and experimental papers as well as high-quality review papers. Submissions should follow the generally accepted structure for journal articles with basic elements: title, abstract, introduction, results, conclusions, and references.
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