肺癌中PI3K信号通路的非编码rna和调控：最新见解和潜在临床应用

IF 5.9 3区生物学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY

Non-coding RNA Research Pub Date : 2024-12-03 DOI:10.1016/j.ncrna.2024.11.006

Mehrdad Hashemi , Asal Abolghasemi Fard , Bita Pakshad , Pezhman Shafiei Asheghabadi , Amineh Hosseinkhani , Atena Sadat Hosseini , Parham Moradi , Mohammadreza Mohammadbeygi Niye , Ghazal Najafi , Mohadeseh Farahzadi , Saloomeh Khoushab , Afshin Taheriazam , Najma Farahani , Mahya Mohammadi , Salman Daneshi , Noushin Nabavi , Maliheh Entezari

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引用次数: 0

摘要

肺癌（LC）是全球癌症相关死亡的最常见原因之一。研究表明，目前药物治疗的预后受到多种因素的影响，包括晚期、肿瘤复发、无法获得适当的治疗，最重要的是化疗耐药。非编码rna （ncRNAs）有助于肿瘤的发展，其中一些作为肿瘤抑制因子，另一些作为致癌基因。磷酸肌肽3-激酶(PI3Ks)/AKT丝氨酸/苏氨酸激酶通路是ncrna在癌症中最重要的共同靶点之一，广泛应用于调节细胞周期和多种生物过程，包括细胞生长、移动存活、代谢活性和蛋白质产生。发现ncRNA-PI3K/AKT信号传导的生物学特性可能会导致癌症诊断和治疗的进步。因此，我们研究了PI3K/ akt相关ncrna在肺癌临床特征中的表达和作用，以及它们作为肺癌诊断、预后和治疗的潜在生物标志物的功能。

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Non-coding RNAs and regulation of the PI3K signaling pathway in lung cancer: Recent insights and potential clinical applications

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Non-coding RNAs and regulation of the PI3K signaling pathway in lung cancer: Recent insights and potential clinical applications

Lung cancer (LC) is one of the most common causes of cancer-related death worldwide. It has been demonstrated that the prognosis of current drug treatments is affected by a variety of factors, including late stage, tumor recurrence, inaccessibility to appropriate treatments, and, most importantly, chemotherapy resistance. Non-coding RNAs (ncRNAs) contribute to tumor development, with some acting as tumor suppressors and others as oncogenes. The phosphoinositide 3-kinase (PI3Ks)/AKT serine/threonine kinase pathway is one of the most important common targets of ncRNAs in cancer, which is widely applied to modulate the cell cycle and a variety of biological processes, including cell growth, mobility survival, metabolic activity, and protein production. Discovering the biology of ncRNA-PI3K/AKT signaling may lead to advances in cancer diagnosis and treatment. As a result, we investigated the expression and role of PI3K/AKT-related ncRNAs in clinical characteristics of lung cancer, as well as their functions as potential biomarkers in lung cancer diagnosis, prognosis, and treatment.

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来源期刊

Non-coding RNA Research Medicine-Biochemistry (medical)

CiteScore

7.70

自引率

6.00%

发文量

审稿时长

49 days

期刊介绍： Non-coding RNA Research aims to publish high quality research and review articles on the mechanistic role of non-coding RNAs in all human diseases. This interdisciplinary journal will welcome research dealing with all aspects of non-coding RNAs-their biogenesis, regulation and role in disease progression. The focus of this journal will be to publish translational studies as well as well-designed basic studies with translational and clinical implications. The non-coding RNAs of particular interest will be microRNAs (miRNAs), small interfering RNAs (siRNAs), small nucleolar RNAs (snoRNAs), U-RNAs/small nuclear RNAs (snRNAs), exosomal/extracellular RNAs (exRNAs), Piwi-interacting RNAs (piRNAs) and long non-coding RNAs. Topics of interest will include, but not limited to: -Regulation of non-coding RNAs -Targets and regulatory functions of non-coding RNAs -Epigenetics and non-coding RNAs -Biological functions of non-coding RNAs -Non-coding RNAs as biomarkers -Non-coding RNA-based therapeutics -Prognostic value of non-coding RNAs -Pharmacological studies involving non-coding RNAs -Population based and epidemiological studies -Gene expression / proteomics / computational / pathway analysis-based studies on non-coding RNAs with functional validation -Novel strategies to manipulate non-coding RNAs expression and function -Clinical studies on evaluation of non-coding RNAs The journal will strive to disseminate cutting edge research, showcasing the ever-evolving importance of non-coding RNAs in modern day research and medicine.