药物性认知障碍。

IF 4 2区 医学 Q1 PHARMACOLOGY & PHARMACY
Drug Safety Pub Date : 2025-04-01 Epub Date: 2024-12-24 DOI:10.1007/s40264-024-01506-5
Arne Reimers, Per Odin, Hanna Ljung
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引用次数: 0

摘要

药物性认知障碍(DICI)是一种公认的,但尚未得到充分认识的多种药物治疗并发症。虽然有大量关于DICI的科学文献,但大多数论文都是关于老年人的药物性痴呆和一种特定的药物类别。然而,DICI也包括亚临床症状、领域特定形式的认知障碍、轻度认知障碍(MCI)和谵妄。即使是轻度的DICI,如果不加以认识,也会造成有害的终身后果。此外,DICI也发生在年轻人和儿童中,据报道与许多不同的药物类别有关。本综述的目的是通过概述观察到的DICI的类型和症状以及各种药物类别(抗癫痫药物、抗抑郁药物、抗帕金森药物、抗精神病药物、锂、苯二氮卓类药物/ z类药物、阿片类药物、第一代抗组胺药、尿失禁药物、质子泵抑制剂、糖皮质激素、非甾体抗炎药、他汀类药物、降压药和化疗药物)的潜在机制来提高对DICI的认识。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Drug-Induced Cognitive Impairment.

Drug-induced cognitive impairment (DICI) is a well-established, yet under-recognised, complication of many types of pharmacological treatment. While there is a large body of scientific literature on DICI, most papers are about drug-induced dementia in the elderly and one specific drug class. However, DICI also comprises subclinical symptoms, domain-specific forms of cognitive impairment as well as mild cognitive impairment (MCI), and delirium. Even mild forms of DICI, if not recognised as such, can have deleterious and life-long consequences. In addition, DICI also occurs in younger adults and in children, and has been reported with many different drug classes. The aim of this review is to raise awareness of DICI by providing an overview on the type(s) and symptoms of observed DICI and the suspected underlying mechanism(s) for various drug classes: antiseizure medications, antidepressants, antiparkinsonian drugs, antipsychotics, lithium, benzodiazepines/Z-drugs, opioids, first-generation antihistamines, drugs for urinary incontinence, proton pump inhibitors, glucocorticoids, NSAIDs, statins, antihypertensives, and chemotherapeutic agents.

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来源期刊
Drug Safety
Drug Safety 医学-毒理学
CiteScore
7.60
自引率
7.10%
发文量
112
审稿时长
6-12 weeks
期刊介绍: Drug Safety is the official journal of the International Society of Pharmacovigilance. The journal includes: Overviews of contentious or emerging issues. Comprehensive narrative reviews that provide an authoritative source of information on epidemiology, clinical features, prevention and management of adverse effects of individual drugs and drug classes. In-depth benefit-risk assessment of adverse effect and efficacy data for a drug in a defined therapeutic area. Systematic reviews (with or without meta-analyses) that collate empirical evidence to answer a specific research question, using explicit, systematic methods as outlined by the PRISMA statement. Original research articles reporting the results of well-designed studies in disciplines such as pharmacoepidemiology, pharmacovigilance, pharmacology and toxicology, and pharmacogenomics. Editorials and commentaries on topical issues. Additional digital features (including animated abstracts, video abstracts, slide decks, audio slides, instructional videos, infographics, podcasts and animations) can be published with articles; these are designed to increase the visibility, readership and educational value of the journal’s content. In addition, articles published in Drug Safety Drugs may be accompanied by plain language summaries to assist readers who have some knowledge of, but not in-depth expertise in, the area to understand important medical advances.
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