氘化策略在药物设计中的应用。

IF 3.6 4区医学 Q2 CHEMISTRY, MEDICINAL

ChemMedChem Pub Date : 2024-12-23 DOI:10.1002/cmdc.202400836

Yuzhu Chen, Yunfei Du

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引用次数: 0

摘要

氘化药物是由药物中的一个质子原子与一个氘原子进行微妙的交换而衍生出来的，从药物特性的角度来看，氘化药物与母体药物有着显著的差异。氘化药物由于具有改善药代动力学性质、降低毒性、抑制手性药物间相互转化和限制药物间相互作用等优点，引起了药物化学家的广泛关注。本文重点介绍了氘化策略在药物设计中的应用，并对市场上所有可获得的氘化药物或正在研究的氘化制剂的进展进行了总结，旨在为所有从事这一药物开发方向的研究人员提供参考。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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The Application of Deuteration Strategy in Drug Design.

Deuterated drugs, which are derived from the subtle exchange of a protium atom with a deuterium atom in drug molecules, exhibit significant differences in pharmaceutical characteristics compared to their parent drugs. With the advantages of improving pharmacokinetic properties, reducing toxicity, inhibiting the interconversion between chiral drugs and restricting drug interactions, deuterated drugs have attracted widespread attention from medicinal chemists. This review highlights the application of deuteration strategies in drug design, summarizing the progress of all deuterated drugs available in the market or still under investigation to provide a reference for all researchers engaged deuterated drug development.

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来源期刊

ChemMedChem 医学-药学

CiteScore

6.70

自引率

2.90%

发文量

280

审稿时长

1 months

期刊介绍： Quality research. Outstanding publications. With an impact factor of 3.124 (2019), ChemMedChem is a top journal for research at the interface of chemistry, biology and medicine. It is published on behalf of Chemistry Europe, an association of 16 European chemical societies. ChemMedChem publishes primary as well as critical secondary and tertiary information from authors across and for the world. Its mission is to integrate the wide and flourishing field of medicinal and pharmaceutical sciences, ranging from drug design and discovery to drug development and delivery, from molecular modeling to combinatorial chemistry, from target validation to lead generation and ADMET studies. ChemMedChem typically covers topics on small molecules, therapeutic macromolecules, peptides, peptidomimetics, and aptamers, protein-drug conjugates, nucleic acid therapies, and beginning 2017, nanomedicine, particularly 1) targeted nanodelivery, 2) theranostic nanoparticles, and 3) nanodrugs. Contents ChemMedChem publishes an attractive mixture of: Full Papers and Communications Reviews and Minireviews Patent Reviews Highlights and Concepts Book and Multimedia Reviews.