意大利17例海洋分枝杆菌感染：多中心回顾性研究。

IF 2.1 4区医学 Q3 INFECTIOUS DISEASES

Diagnostic microbiology and infectious disease Pub Date : 2024-12-16 DOI:10.1016/j.diagmicrobio.2024.116656

Bianca Granozzi , Martina Casarini , Niccolò Riccardi , Angelo Roberto Raccagni , Silvia Nozza , Filippo Bartalesi , Agostina Pontarelli , Jessica Mencarini , Sara Occhineri , Laura Rindi , Marco Falcone , Marina Tadolini

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引用次数: 0

摘要

海洋分枝杆菌感染是罕见的，被误诊和漏诊，但可引起严重的临床症状，特别是如果诊断较晚和患者免疫功能低下。治疗包括长期抗生素治疗，必要时联合手术治疗。我们对来自意大利五家医院的数据进行了一项多中心回顾性研究，描述了诊断为海洋分枝杆菌感染的受试者的流行病学、临床、细菌学特征和治疗结果。在研究期间，共招募了17名受试者。从症状出现到诊断的中位时间为124天。17例中有13例为细菌学确诊病例。在所有病例中，除一例外，至少使用了两种抗生素，治疗中位数为6个月，导致临床缓解。通常，海洋支原体感染的诊断被延迟，并且在很大程度上仍然是假定的。为了更好地了解最合适的治疗方案和持续时间，前瞻性研究和随机对照试验是必要的。

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Seventeen cases of Mycobacterium marinum infection in Italy: A multicenter retrospective study

Mycobacterium marinum infection is rare, misrecognized and underdiagnosed but can cause severe clinical pictures, especially if the diagnosis is late and the patient is immunocompromised. Treatment includes long-term antibiotic therapy combined with surgical therapy when necessary.

We performed a multicenter retrospective study with data from five Italian hospitals describing the epidemiological, clinical, bacteriological characteristics, and treatment outcome of subjects diagnosed with M. marinum infection.

During the study period 17 subjects were enrolled. The median time from symptoms onset to diagnosis was 124 days. Thirteen out of 17 were bacteriologically confirmed cases. In all cases, expect one, at least two antibiotics were used with a median of 6 months of treatment, leading to clinical resolution.

Too often, the diagnosis of M. marinum infection is delayed and it remains largely presumptive. Prospective studies and randomized controlled trials are necessary to better understand the most appropriate therapeutic regimen and duration.

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来源期刊

Diagnostic microbiology and infectious disease 医学-传染病学

CiteScore

5.30

自引率

3.40%

发文量

149

审稿时长

56 days

期刊介绍： Diagnostic Microbiology and Infectious Disease keeps you informed of the latest developments in clinical microbiology and the diagnosis and treatment of infectious diseases. Packed with rigorously peer-reviewed articles and studies in bacteriology, immunology, immunoserology, infectious diseases, mycology, parasitology, and virology, the journal examines new procedures, unusual cases, controversial issues, and important new literature. Diagnostic Microbiology and Infectious Disease distinguished independent editorial board, consisting of experts from many medical specialties, ensures you extensive and authoritative coverage.