[肌动蛋白和肌凝蛋白在细胞核中的作用:已知蛋白的新功能]。

Q3 Medicine
A A Saidova, I A Vorobjev
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引用次数: 0

摘要

肌动蛋白及其运动蛋白肌球蛋白在细胞质中的功能已被研究了100多年,但这些蛋白在细胞核中的存在及其功能直到最近才成为争论的问题。最近的数据已经阐明了肌动蛋白和肌球蛋白分子在控制细胞核动力学过程、染色质组织和基因组完整性方面的作用。新的显微镜技术和改良的肌动蛋白结合探针的使用首次使直接观察活细胞核中肌动蛋白丝的聚合成为可能。在这里,我们讨论了控制肌动蛋白和肌球蛋白在细胞核和细胞质之间动态平衡的过程,以及这些蛋白质在转录、DNA修复、染色质重组、肿瘤转化和细胞分化中的作用。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
[What Actin and Myosin Do in the Nucleus: New Functions of the Well-Known Proteins].

The functions of actin and its motor proteins myosins in the cytoplasm have been the subject of research for more than 100 years, but the existence and function of these proteins in the nucleus has been a matter of debate until recently. Recent data has clarified the role of actin and myosin molecules in controlling the dynamics of processes in the cell nucleus, chromatin organization and genome integrity. New microscopy techniques and the use of modified actin-binding probes have made it possible for the first time to directly visualize the polymerization of actin filaments in the nucleus of living cells. Here we discuss the processes that control the dynamic balance of actin and myosins between the nucleus and the cytoplasm, as well as the role of these proteins in the regulation of transcription, DNA repair, chromatin reorganization, tumor transformation and cell differentiation.

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来源期刊
Molekulyarnaya Biologiya
Molekulyarnaya Biologiya Medicine-Medicine (all)
CiteScore
0.70
自引率
0.00%
发文量
131
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