Pojsakorn Danpanichkul, Kwanjit Duangsonk, Ethan Kai Jun Tham, Primrose Tothanarungroj, Thanida Auttapracha, Vitchapong Prasitsumrit, Benedix Sim, Daniel Tung, Romelia Barba, Robert J. Wong, Lorenzo Leggio, Ju Dong Yang, Vincent L. Chen, Mazen Noureddin, Luis Antonio Díaz, Juan Pablo Arab, Karn Wijarnpreecha, Suthat Liangpunsakul
{"title":"美国老年人因饮酒导致的酒精使用障碍、酒精相关肝病和肝癌的死亡率增加：2000 年至 2021 年。","authors":"Pojsakorn Danpanichkul, Kwanjit Duangsonk, Ethan Kai Jun Tham, Primrose Tothanarungroj, Thanida Auttapracha, Vitchapong Prasitsumrit, Benedix Sim, Daniel Tung, Romelia Barba, Robert J. Wong, Lorenzo Leggio, Ju Dong Yang, Vincent L. Chen, Mazen Noureddin, Luis Antonio Díaz, Juan Pablo Arab, Karn Wijarnpreecha, Suthat Liangpunsakul","doi":"10.1111/acer.15516","DOIUrl":null,"url":null,"abstract":"<div>\n \n \n <section>\n \n <h3> Background</h3>\n \n <p>To investigate the trends in alcohol-associated liver disease (ALD), liver cancer from alcohol, and alcohol use disorder (AUD) burden among older adults in the United States (US).</p>\n </section>\n \n <section>\n \n <h3> Methods</h3>\n \n <p>We gathered the ALD, liver cancer from alcohol, and AUD prevalence, mortality, and age-standardized rates (ASRs) from the Global Burden of Disease (GBD) Study 2021 between 2010 and 2021. We estimated the annual percent change (APC) with confidence intervals (CIs) for the burden of ALD, liver cancer from alcohol, and AUD in older adults (>70 years) in the United States. The findings were contrasted with global estimates and categorized by sex and state.</p>\n </section>\n \n <section>\n \n <h3> Results</h3>\n \n <p>In 2021, there were approximately 512,340 cases of AUD, 56,990 cases of ALD, and 4490 cases of primary liver cancer from alcohol among older adults in the United States. In contrast to declining ASRs of prevalence and mortality in the global burden, these parameters were increased in older adults in the United States. From 2000 to 2021, prevalence from AUD (APC: 0.54%, 95% CI 0.43% to 0.65%), ALD (APC + 0.54%, 95% CI 0.22% to 0.86%), and primary liver cancer from alcohol (APC 2.93%, 95% CI 2.76% to 3.11%) increased. Forty states in the United States exhibited a rise in the prevalence rates of ALD in older adults.</p>\n </section>\n \n <section>\n \n <h3> Conclusion</h3>\n \n <p>Our findings highlighted the increased prevalence and mortality of AUD, ALD, and primary liver cancer from alcohol among older adults in the United Sates, contrasting with the decline in global trends. Public health strategies on ALD, AUD, and primary liver cancer from alcohol, which targets older adults, are urgently needed.</p>\n </section>\n </div>","PeriodicalId":72145,"journal":{"name":"Alcohol (Hanover, York County, Pa.)","volume":"49 2","pages":"368-378"},"PeriodicalIF":3.0000,"publicationDate":"2024-12-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1111/acer.15516","citationCount":"0","resultStr":"{\"title\":\"Increased mortality from alcohol use disorder, alcohol-associated liver disease, and liver cancer from alcohol among older adults in the United States: 2000 to 2021\",\"authors\":\"Pojsakorn Danpanichkul, Kwanjit Duangsonk, Ethan Kai Jun Tham, Primrose Tothanarungroj, Thanida Auttapracha, Vitchapong Prasitsumrit, Benedix Sim, Daniel Tung, Romelia Barba, Robert J. Wong, Lorenzo Leggio, Ju Dong Yang, Vincent L. Chen, Mazen Noureddin, Luis Antonio Díaz, Juan Pablo Arab, Karn Wijarnpreecha, Suthat Liangpunsakul\",\"doi\":\"10.1111/acer.15516\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div>\\n \\n \\n <section>\\n \\n <h3> Background</h3>\\n \\n <p>To investigate the trends in alcohol-associated liver disease (ALD), liver cancer from alcohol, and alcohol use disorder (AUD) burden among older adults in the United States (US).</p>\\n </section>\\n \\n <section>\\n \\n <h3> Methods</h3>\\n \\n <p>We gathered the ALD, liver cancer from alcohol, and AUD prevalence, mortality, and age-standardized rates (ASRs) from the Global Burden of Disease (GBD) Study 2021 between 2010 and 2021. We estimated the annual percent change (APC) with confidence intervals (CIs) for the burden of ALD, liver cancer from alcohol, and AUD in older adults (>70 years) in the United States. The findings were contrasted with global estimates and categorized by sex and state.</p>\\n </section>\\n \\n <section>\\n \\n <h3> Results</h3>\\n \\n <p>In 2021, there were approximately 512,340 cases of AUD, 56,990 cases of ALD, and 4490 cases of primary liver cancer from alcohol among older adults in the United States. In contrast to declining ASRs of prevalence and mortality in the global burden, these parameters were increased in older adults in the United States. From 2000 to 2021, prevalence from AUD (APC: 0.54%, 95% CI 0.43% to 0.65%), ALD (APC + 0.54%, 95% CI 0.22% to 0.86%), and primary liver cancer from alcohol (APC 2.93%, 95% CI 2.76% to 3.11%) increased. Forty states in the United States exhibited a rise in the prevalence rates of ALD in older adults.</p>\\n </section>\\n \\n <section>\\n \\n <h3> Conclusion</h3>\\n \\n <p>Our findings highlighted the increased prevalence and mortality of AUD, ALD, and primary liver cancer from alcohol among older adults in the United Sates, contrasting with the decline in global trends. Public health strategies on ALD, AUD, and primary liver cancer from alcohol, which targets older adults, are urgently needed.</p>\\n </section>\\n </div>\",\"PeriodicalId\":72145,\"journal\":{\"name\":\"Alcohol (Hanover, York County, Pa.)\",\"volume\":\"49 2\",\"pages\":\"368-378\"},\"PeriodicalIF\":3.0000,\"publicationDate\":\"2024-12-19\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://onlinelibrary.wiley.com/doi/epdf/10.1111/acer.15516\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Alcohol (Hanover, York County, Pa.)\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://onlinelibrary.wiley.com/doi/10.1111/acer.15516\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"SUBSTANCE ABUSE\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Alcohol (Hanover, York County, Pa.)","FirstCategoryId":"1085","ListUrlMain":"https://onlinelibrary.wiley.com/doi/10.1111/acer.15516","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"SUBSTANCE ABUSE","Score":null,"Total":0}
引用次数: 0
摘要
背景：研究美国老年人酒精相关性肝病（ALD）、酒精引起的肝癌和酒精使用障碍（AUD）负担的趋势。方法：我们从2010年至2021年的全球疾病负担（GBD）研究中收集了ALD、酒精导致的肝癌和AUD的患病率、死亡率和年龄标准化率（ASRs）。我们估计了美国老年人（60 - 70岁）ALD、酒精肝癌和AUD负担的年百分比变化（APC）和置信区间（CIs）。研究结果与全球估计数据进行了对比，并按性别和州进行了分类。结果：2021年，美国老年人中约有512,340例AUD， 56,990例ALD和4490例酒精引起的原发性肝癌。与全球负担的asr患病率和死亡率下降相反，这些参数在美国老年人中增加。从2000年到2021年，AUD （APC: 0.54%, 95% CI 0.43%至0.65%）、ALD （APC + 0.54%, 95% CI 0.22%至0.86%）和酒精引起的原发性肝癌（APC 2.93%, 95% CI 2.76%至3.11%）的患病率增加。美国40个州的老年人中ALD患病率有所上升。结论：我们的研究结果强调，在美国老年人中，酒精引起的AUD、ALD和原发性肝癌的患病率和死亡率增加，与全球趋势的下降形成鲜明对比。目前迫切需要针对老年人的ALD、AUD和酒精引起的原发性肝癌的公共卫生策略。
Increased mortality from alcohol use disorder, alcohol-associated liver disease, and liver cancer from alcohol among older adults in the United States: 2000 to 2021
Background
To investigate the trends in alcohol-associated liver disease (ALD), liver cancer from alcohol, and alcohol use disorder (AUD) burden among older adults in the United States (US).
Methods
We gathered the ALD, liver cancer from alcohol, and AUD prevalence, mortality, and age-standardized rates (ASRs) from the Global Burden of Disease (GBD) Study 2021 between 2010 and 2021. We estimated the annual percent change (APC) with confidence intervals (CIs) for the burden of ALD, liver cancer from alcohol, and AUD in older adults (>70 years) in the United States. The findings were contrasted with global estimates and categorized by sex and state.
Results
In 2021, there were approximately 512,340 cases of AUD, 56,990 cases of ALD, and 4490 cases of primary liver cancer from alcohol among older adults in the United States. In contrast to declining ASRs of prevalence and mortality in the global burden, these parameters were increased in older adults in the United States. From 2000 to 2021, prevalence from AUD (APC: 0.54%, 95% CI 0.43% to 0.65%), ALD (APC + 0.54%, 95% CI 0.22% to 0.86%), and primary liver cancer from alcohol (APC 2.93%, 95% CI 2.76% to 3.11%) increased. Forty states in the United States exhibited a rise in the prevalence rates of ALD in older adults.
Conclusion
Our findings highlighted the increased prevalence and mortality of AUD, ALD, and primary liver cancer from alcohol among older adults in the United Sates, contrasting with the decline in global trends. Public health strategies on ALD, AUD, and primary liver cancer from alcohol, which targets older adults, are urgently needed.
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