在环上增加一个扭曲：DNA超螺旋在SMC蛋白复合体染色体组织中的作用。

IF 3.8 3区生物学 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY

Biochemical Society transactions Pub Date : 2024-12-19 DOI:10.1042/BST20240650

Antonio Valdés, Christian H Haering

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引用次数: 0

摘要

染色体结构维持（SMC）蛋白复合物，包括黏结蛋白、凝聚蛋白和Smc5/6复合物，在染色体生物学的各种过程中是不可或缺的。尽管这些复合物的作用各不相同，但它们有两个关键特性：将DNA挤压成大环状结构的能力，以及改变DNA双螺旋结构的超螺旋度的能力。在这篇综述中，我们探讨真核SMC复合物对DNA拓扑结构的影响，讨论其潜在的生理功能，并讨论新的结构见解，可能解释这些复合物如何介导DNA拓扑结构的变化。

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Adding a twist to the loops: the role of DNA superhelicity in the organization of chromosomes by SMC protein complexes.

Structural maintenance of chromosomes (SMC) protein complexes, including cohesin, condensin, and the Smc5/6 complex, are integral to various processes in chromosome biology. Despite their distinct roles, these complexes share two key properties: the ability to extrude DNA into large loop structures and the capacity to alter the superhelicity of the DNA double helix. In this review, we explore the influence of eukaryotic SMC complexes on DNA topology, debate its potential physiological function, and discuss new structural insights that may explain how these complexes mediate changes in DNA topology.

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来源期刊

Biochemical Society transactions 生物-生化与分子生物学

CiteScore

7.80

自引率

0.00%

发文量

351

审稿时长

3-6 weeks

期刊介绍： Biochemical Society Transactions is the reviews journal of the Biochemical Society. Publishing concise reviews written by experts in the field, providing a timely snapshot of the latest developments across all areas of the molecular and cellular biosciences. Elevating our authors’ ideas and expertise, each review includes a perspectives section where authors offer comment on the latest advances, a glimpse of future challenges and highlighting the importance of associated research areas in far broader contexts.