膀胱内卡介苗治疗后并发间质性肺炎和播散性卡介苗感染1例。

IF 1 4区医学 Q3 MEDICINE, GENERAL & INTERNAL

Internal Medicine Pub Date : 2024-12-19 DOI:10.2169/internalmedicine.4659-24

Fumi Mochizuki, Midori Hanazawa, Manabu Komine, Hiroya Sunabe, Sayumi Koyanagi, Yuki Yamazaki, Ayumi Watanabe, Takafumi Shimada, Kazuki Obara, Hiroaki Iijima, Koichi Kurishima, Hiroichi Ishikawa

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引用次数: 0

摘要

一例83岁男性膀胱癌患者膀胱内卡介苗治疗后出现持续发热。胸部计算机断层扫描（CT）和支气管镜检查显示弥漫性磨玻璃影伴多发微结节和淋巴细胞为主的支气管肺泡灌洗液，CD4/CD8比值高。因此，对间质性肺炎的皮质治疗开始了。呼吸道标本抗快染色阴性；然而，根据CT结果提示播散性卡介苗感染，增加了抗结核治疗。入院后50天，在最初的痰培养中发现牛卡介苗分枝杆菌。膀胱内卡介苗治疗后胸部影像学异常的患者应考虑合并间质性肺炎和卡介苗感染。

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Concomitant Interstitial Pneumonia and Disseminated BCG Infection after Intravesical BCG Therapy: A Case Report.

An 83-year-old man presented with persistent fever after intravesical BCG therapy for bladder cancer. Chest computed tomography (CT) and bronchoscopy revealed diffuse ground-glass opacities with multiple micronodules and lymphocyte-predominant bronchoalveolar lavage fluid with a high CD4/CD8 ratio, respectively. Therefore, corticotherapy for interstitial pneumonia was initiated. Anti-fast staining of the respiratory specimens was negative; however, anti-tuberculosis treatment was added based on CT findings suggesting disseminated BCG infection. Fifty days post-admission, Mycobacterium bovis BCG was identified in the initial sputum cultures. Concomitant interstitial pneumonia and BCG infection should be considered in patients with abnormal chest imaging following intravesical BCG therapy.

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来源期刊

Internal Medicine 医学-医学：内科

CiteScore

1.90

自引率

8.30%

发文量

审稿时长

2.2 months

期刊介绍： Internal Medicine is an open-access online only journal published monthly by the Japanese Society of Internal Medicine. Articles must be prepared in accordance with "The Uniform Requirements for Manuscripts Submitted to Biomedical Journals (see Annals of Internal Medicine 108: 258-265, 1988), must be contributed solely to the Internal Medicine, and become the property of the Japanese Society of Internal Medicine. Statements contained therein are the responsibility of the author(s). The Society reserves copyright and renewal on all published material and such material may not be reproduced in any form without the written permission of the Society.