抗菌肽的作用机制、生物学特性及发展前景

IF 1 4区 生物学 Q4 BIOTECHNOLOGY & APPLIED MICROBIOLOGY
X. Ma, Z. Chen, M. Long
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引用次数: 0

摘要

由于近年来抗生素的过度使用,导致耐药感染的流行率增加,耐药微生物正在演变。因此,目前正在开发的抗生素远远不足以治疗多药耐药带来的疾病和问题。抗菌肽(AMPs)广泛存在于生物界,可能有助于解决这一问题。抗菌肽通过多种复杂的作用机制,对耐药菌的生长具有非常有效的抑制作用,并且具有很高的靶向特异性。与抗生素、蛋白质、聚合物和纳米颗粒等分子的结合是正在研究的提高抗菌肽治疗效果的策略。因此,人们普遍预计它们将成为替代抗生素对抗感染的新方法的基础。本文综述了抗菌肽的作用机制,并重点介绍了抗菌肽的生物学特性和应用前景。它还评估了他们的前景和前进的困难。此外,对抗菌肽偶联物的设计和应用的抗菌效果进行了总结,为抗菌肽的进一步研究和应用提供有益的参考。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Mechanisms of Action, Biological Characteristics, and Future Prospects: A Review of Antimicrobial Peptides (A Review)

Mechanisms of Action, Biological Characteristics, and Future Prospects: A Review of Antimicrobial Peptides (A Review)

Drug-resistant microbes are evolving as a result of the overuse of antibiotics in recent years leading to an increase in the prevalence of drug-resistant infections. Thus, the antibiotics that are currently in development are far from sufficient to treat illnesses and their problems brought on by multi-drug resistance. Antimicrobial peptides (AMPs), which are widely found in the biological world, may help solve this problem. AMPs are highly effective at inhibiting the growth of drug-resistant bacteria via a variety of complex action mechanisms and also have high target specificity. Conjugation to molecules such as antibiotics, proteins, polymers, and nanoparticles are strategies under investigation to boost the therapeutic efficacy of AMPs. As such, they are widely expected to be the basis of a new way of fighting infection in place of antibiotics. This review primarily focuses on these action mechanisms and highlights the biological characteristics and promising applications of AMPs. It also evaluates their prospects and difficulties moving forward. In addition, the antimicrobial efficacies of the design and application of AMPs’ conjugates are summarized to provide a useful reference for future research on AMPs and their application.

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来源期刊
Applied Biochemistry and Microbiology
Applied Biochemistry and Microbiology 生物-生物工程与应用微生物
CiteScore
1.70
自引率
12.50%
发文量
75
审稿时长
6-12 weeks
期刊介绍: Applied Biochemistry and Microbiology is an international peer reviewed journal that publishes original articles on biochemistry and microbiology that have or may have practical applications. The studies include: enzymes and mechanisms of enzymatic reactions, biosynthesis of low and high molecular physiologically active compounds; the studies of their structure and properties; biogenesis and pathways of their regulation; metabolism of producers of biologically active compounds, biocatalysis in organic synthesis, applied genetics of microorganisms, applied enzymology; protein and metabolic engineering, biochemical bases of phytoimmunity, applied aspects of biochemical and immunochemical analysis; biodegradation of xenobiotics; biosensors; biomedical research (without clinical studies). Along with experimental works, the journal publishes descriptions of novel research techniques and reviews on selected topics.
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