{"title":"新的单糖促进烟酸衍生物：合成、结构表征和生物学评价","authors":"A. M. Youssef, N. A. Abdul-Rida","doi":"10.1134/S1070363224110197","DOIUrl":null,"url":null,"abstract":"<p>New niacin derivatives conjugated with monosaccharides were synthesized through a series of reactions and then evaluated <i>in vitro</i> as antimicrobial and antioxidant agents. Briefly, 4bromonicotinic acid was reacted with hydrazine hydrate to give 4-bromonicotinohydrazide in a single step. Next, the derivative obtained was condensed with various monosaccharides via the Schiff base reaction. Biologically, the antioxidant activity of these compounds was investigated by phosphomolybdate test, results obtained in this test revealed encouraging activity for some of synthesized derivatives with good EC<sub>50</sub> values compared to ascorbic acid. In addition, the antimicrobial activity of synthesized derivatives showed good inhibition against both <i>C. albicans</i> and <i>E. coli</i> compared to standard drugs.</p>","PeriodicalId":761,"journal":{"name":"Russian Journal of General Chemistry","volume":"94 11","pages":"2967 - 2971"},"PeriodicalIF":0.9000,"publicationDate":"2024-12-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"New Niacin Derivatives Boosting with Monosaccharide: Synthesis, Structural Characterization, and Biological Evaluation\",\"authors\":\"A. M. Youssef, N. A. Abdul-Rida\",\"doi\":\"10.1134/S1070363224110197\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p>New niacin derivatives conjugated with monosaccharides were synthesized through a series of reactions and then evaluated <i>in vitro</i> as antimicrobial and antioxidant agents. Briefly, 4bromonicotinic acid was reacted with hydrazine hydrate to give 4-bromonicotinohydrazide in a single step. Next, the derivative obtained was condensed with various monosaccharides via the Schiff base reaction. Biologically, the antioxidant activity of these compounds was investigated by phosphomolybdate test, results obtained in this test revealed encouraging activity for some of synthesized derivatives with good EC<sub>50</sub> values compared to ascorbic acid. In addition, the antimicrobial activity of synthesized derivatives showed good inhibition against both <i>C. albicans</i> and <i>E. coli</i> compared to standard drugs.</p>\",\"PeriodicalId\":761,\"journal\":{\"name\":\"Russian Journal of General Chemistry\",\"volume\":\"94 11\",\"pages\":\"2967 - 2971\"},\"PeriodicalIF\":0.9000,\"publicationDate\":\"2024-12-17\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Russian Journal of General Chemistry\",\"FirstCategoryId\":\"92\",\"ListUrlMain\":\"https://link.springer.com/article/10.1134/S1070363224110197\",\"RegionNum\":4,\"RegionCategory\":\"化学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q4\",\"JCRName\":\"CHEMISTRY, MULTIDISCIPLINARY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Russian Journal of General Chemistry","FirstCategoryId":"92","ListUrlMain":"https://link.springer.com/article/10.1134/S1070363224110197","RegionNum":4,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q4","JCRName":"CHEMISTRY, MULTIDISCIPLINARY","Score":null,"Total":0}
New Niacin Derivatives Boosting with Monosaccharide: Synthesis, Structural Characterization, and Biological Evaluation
New niacin derivatives conjugated with monosaccharides were synthesized through a series of reactions and then evaluated in vitro as antimicrobial and antioxidant agents. Briefly, 4bromonicotinic acid was reacted with hydrazine hydrate to give 4-bromonicotinohydrazide in a single step. Next, the derivative obtained was condensed with various monosaccharides via the Schiff base reaction. Biologically, the antioxidant activity of these compounds was investigated by phosphomolybdate test, results obtained in this test revealed encouraging activity for some of synthesized derivatives with good EC50 values compared to ascorbic acid. In addition, the antimicrobial activity of synthesized derivatives showed good inhibition against both C. albicans and E. coli compared to standard drugs.
期刊介绍：
Russian Journal of General Chemistry is a journal that covers many problems that are of general interest to the whole community of chemists. The journal is the successor to Russia’s first chemical journal, Zhurnal Russkogo Khimicheskogo Obshchestva (Journal of the Russian Chemical Society ) founded in 1869 to cover all aspects of chemistry. Now the journal is focused on the interdisciplinary areas of chemistry (organometallics, organometalloids, organoinorganic complexes, mechanochemistry, nanochemistry, etc.), new achievements and long-term results in the field. The journal publishes reviews, current scientific papers, letters to the editor, and discussion papers.
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