IF 1.9 3区 农林科学 Q3 DERMATOLOGY
Masahiko Nagata, Jin Kozakai, Aya Yoshida, Kana Kameyama, Hiromi Oboso, Hisanori Muto, Shoji Ogino, Toshihiro Tsukui
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引用次数: 0

摘要

背景:过敏原免疫疗法被用作犬特应性皮炎(cAD)的病因治疗:过敏原免疫疗法是犬特应性皮炎(cAD)的病因治疗方法:目的:评估使用拉普兰结合重组 Der f 2(rDf2-P)进行免疫治疗一年的抗炎效果:21只患有cAD的私人饲养犬:抗炎药物治疗≥4周后出现轻微临床症状的犬接受rDf2-P免疫治疗1年。计算每月用药评分(MS),并使用犬特应性皮炎范围和严重程度指数(CADESI)-04、柴犬 cAD 湿疹面积和严重程度以及瘙痒评分评估临床症状。在为期6周的诱导阶段,在初始剂量和最终剂量时评估血清胸腺和活化调节趋化因子(TARC)/C-C Motif趋化因子配体-17(CCL17)的浓度,此后每3个月评估一次,为期1年,共16例:结果:在2.5个月、4.5个月、7.5个月、10.5个月和13.5个月时,平均MS分别明显下降43.0%(p = 0.022)、60.9%(p = 0.003)、70.0%(p = 0.0004)、58.7%(p = 0.0004)和49.3%(p = 0.029)。在 4.5 个月和 13.5 个月时,经 MS 评估和临床评分调整后,分别有 12 只(57.1%)和 11 只(52.4%)狗的省药效果被评为优,3 只(14.3%)和 1 只(4.8%)狗的省药效果被评为良,0 只和 3 只(14.3%)狗的省药效果被评为中,6 只(28.6%)和 5 只(23.8%)狗的省药效果被评为差。在CADESI-04评分(17)较低的样本中,血清TARC/CCL17浓度明显较低(p = 0.0002):Der f 2-P 免疫疗法可迅速减少抗炎药物的使用,是治疗 cAD 的有效前瞻性疗法。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Immunotherapy using pullulan-conjugated Der f 2 allergen in canine atopic dermatitis: An anti-inflammatory agent-sparing approach.

Background: Allergen immunotherapy is used as aetiological treatment for canine atopic dermatitis (cAD).

Objective: To assess the anti-inflammatory agent-sparing effect over 1 year of immunotherapy using pullulan-conjugated recombinant Der f 2 (rDf2-P).

Animals: Twenty-one privately owned dogs with cAD.

Materials and methods: Dogs with mild clinical signs after ≥4 weeks of anti-inflammatory drug treatment received rDf2-P immunotherapy for 1 year. A monthly medication score (MS) was calculated, and clinical signs were assessed using Canine Atopic Dermatitis Extent and Severity Index (CADESI)-04, cAD Eczema Area and Severity for Shiba Inu and pruritus scores. Serum thymus and activation-regulated chemokine (TARC)/C-C Motif Chemokine Ligand-17 (CCL17) concentrations were assessed at the initial and final doses during the 6-week induction phase and every 3 months for 1 year thereafter in 16 cases.

Results: The mean MS decreased significantly by 43.0% (p = 0.022), 60.9% (p = 0.003), 70.0% (p = 0.0004), 58.7% (p = 0.0004) and 49.3% (p = 0.029) at 2.5, 4.5, 7.5, 10.5 and 13.5 months, respectively. Drug-sparing effects, assessed with MS and adjusted by clinical scores were rated as excellent for 12 (57.1%) and 11 (52.4%) dogs, good for 3 (14.3%) and 1 (4.8%) dogs, fair for 0 and 3 (14.3%) dogs, and poor for 6 (28.6%) and 5 (23.8%) dogs at 4.5 and 13.5 months, respectively. The serum TARC/CCL17 concentrations were significantly lower in the samples with lower CADESI-04 scores (<17) than in those with higher CADESI-04 scores (>17) (p = 0.0002).

Conclusions and clinical relevance: Der f 2-P immunotherapy can lead to a rapid reduction in anti-inflammatory drug use and serve as an effective proactive therapy for cAD.

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来源期刊
Veterinary dermatology
Veterinary dermatology 农林科学-兽医学
CiteScore
3.20
自引率
21.40%
发文量
92
审稿时长
12-24 weeks
期刊介绍: Veterinary Dermatology is a bi-monthly, peer-reviewed, international journal which publishes papers on all aspects of the skin of mammals, birds, reptiles, amphibians and fish. Scientific research papers, clinical case reports and reviews covering the following aspects of dermatology will be considered for publication: -Skin structure (anatomy, histology, ultrastructure) -Skin function (physiology, biochemistry, pharmacology, immunology, genetics) -Skin microbiology and parasitology -Dermatopathology -Pathogenesis, diagnosis and treatment of skin diseases -New disease entities
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