根据骨架化平均扩散率峰值宽度得出的幼年肌阵挛性癫痫患者小血管疾病的证据。

IF 2.7 3区 医学 Q2 CLINICAL NEUROLOGY
Dong Ah Lee, Ho-Joon Lee, Kang Min Park
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引用次数: 0

摘要

目的:骨架化平均扩散率峰值宽度(PSMD)是一种新的白质变化标志物,可能由小血管疾病引起。本研究旨在利用 PSMD 调查幼年肌阵挛性癫痫(JME)患者的白质变化:方法:我们招募了青少年肌阵挛性癫痫患者以及年龄和性别匹配的健康对照组。我们使用三特斯拉磁共振成像扫描仪进行了弥散张量成像(DTI)。我们使用 FSL 程序分几个步骤测量了基于 DTI 的 PSMD,包括预处理、骨骼化、应用自定义遮罩和直方图分析。我们比较了 JME 患者和健康对照组的 PSMD,以及 JME 患者根据抗癫痫药物(ASM)反应得出的 PSMD。我们还对JME患者的PSMD和临床因素进行了相关分析:我们招募了42名新确诊的JME患者和42名健康对照者。JME患者与健康对照组的PSMD存在明显差异。JME患者的PSMD高于健康对照组(2.234 vs. 2.085 × 10-4 mm2/s,p = 0.013)。此外,ASM反应差的JME患者的PSMD高于ASM反应好的患者(2.586 vs. 2.176 × 10-4 mm2/s,p = 0.007)。PSMD与年龄呈正相关(r = 0.364,p = 0.017):结论:JME患者的PSMD高于健康对照组,这表明JME患者的白质发生了变化。此外,白质变化与JME患者的ASM反应有关。这一发现还凸显了PSMD作为检测癫痫患者可能因小血管疾病引起的白质变化的标志物的潜力,这还需要进一步研究。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Evidence of small vessel disease in patients with juvenile myoclonic epilepsy based on the peak width of skeletonized mean diffusivity.

Objectives: Peak width of skeletonized mean diffusivity (PSMD) is a novel marker of white matter changes probably due to small vessel disease. This study aimed to investigate the presence of white matter changes in juvenile myoclonic epilepsy (JME) using PSMD.

Methods: We enrolled patients with JME and age- and sex-matched healthy controls. We performed diffusion tensor imaging (DTI) using a three tesla magnetic resonance imaging scanner. We measured the PSMD based on DTI in several steps, including preprocessing, skeletonization, application of a custom mask, and histogram analysis, using the FSL program. We compared the PSMD between patients with JME and healthy controls and the PSMD according to the antiseizure medication (ASM) response among the patients with JME. We also performed a correlation analysis between the PSMD and clinical factors in patients with JME.

Results: We enrolled the 42 patients with newly diagnosed JME and 42 healthy controls. There was a significant difference in the PSMD between patients with JME and healthy controls. PSMD was higher in patients with JME than in healthy controls (2.234 vs. 2.085 × 10-4 mm2/s, p = 0.013). In addition, the PSMD was higher in patients with JME who were ASM poor responders than in those who were ASM good responders (2.586 vs. 2.176 × 10-4 mm2/s, p = 0.007). The PSMD was positively correlated with age (r = 0.364, p = 0.017).

Conclusion: Patients with JME have a higher PSMD than healthy controls, indicating evidence of white matter changes in patients with JME. In addition, white matter changes are related to the ASM response in patients with JME. This finding also highlights the potential of PSMD as a marker for detecting white matter changes probably due to small vessel disease in patients with epilepsy, which would require further studies.

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来源期刊
Seizure-European Journal of Epilepsy
Seizure-European Journal of Epilepsy 医学-临床神经学
CiteScore
5.60
自引率
6.70%
发文量
231
审稿时长
34 days
期刊介绍: Seizure - European Journal of Epilepsy is an international journal owned by Epilepsy Action (the largest member led epilepsy organisation in the UK). It provides a forum for papers on all topics related to epilepsy and seizure disorders.
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