免疫衰老：癌症生物学中的一个关键角色。

IF 12.1 1区医学 Q1 ONCOLOGY

Seminars in cancer biology Pub Date : 2025-01-01 Epub Date: 2024-12-13 DOI:10.1016/j.semcancer.2024.12.001

Yanru Yang, Linni Fan, Mingyang Li, Zhe Wang

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引用次数: 0

摘要

近年来，随着免疫学技术的快速发展，我们对免疫衰老的认识逐渐加深，但免疫衰老在癌症生物学中的作用尚未完全阐明。了解这些机制和相互作用对肿瘤生物学的发展至关重要。本文综述了免疫衰老的分类和主要特征、癌症中影响免疫细胞衰老的因素、免疫衰老与恶性肿瘤的相互因果循环、免疫衰老作为癌症免疫治疗靶点的潜力等五个重点领域。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Immune senescence: A key player in cancer biology.

With the rapid development of immunological techniques in recent years, our understanding of immune senescence has gradually deepened, but the role of immune senescence in cancer biology remains incompletely elucidated. Understanding these mechanisms and interactions is crucial for the development of tumor biology. This review examines five key areas: the classification and main features of immune senescence, factors influencing immune cell senescence in cancer, the reciprocal causal cycle between immune senescence and malignancy, and the potential of immune senescence as a target for cancer immunotherapy.

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来源期刊

Seminars in cancer biology 医学-肿瘤学

CiteScore

26.80

自引率

4.10%

发文量

347

审稿时长

15.1 weeks

期刊介绍： Seminars in Cancer Biology (YSCBI) is a specialized review journal that focuses on the field of molecular oncology. Its primary objective is to keep scientists up-to-date with the latest developments in this field. The journal adopts a thematic approach, dedicating each issue to an important topic of interest to cancer biologists. These topics cover a range of research areas, including the underlying genetic and molecular causes of cellular transformation and cancer, as well as the molecular basis of potential therapies. To ensure the highest quality and expertise, every issue is supervised by a guest editor or editors who are internationally recognized experts in the respective field. Each issue features approximately eight to twelve authoritative invited reviews that cover various aspects of the chosen subject area. The ultimate goal of each issue of YSCBI is to offer a cohesive, easily comprehensible, and engaging overview of the selected topic. The journal strives to provide scientists with a coordinated and lively examination of the latest developments in the field of molecular oncology.