{"title":"从 limonium sinense 全株中提取的黄酮类化合物及其抗炎活性。","authors":"Ban-Ban Li, Shao-Wei Sun, Shuang Miao, Li-Juan Yang, Xin-Yu Meng, Kai-Kai Gong, Shi-Zhou Qi, Jin-Jie Zhang","doi":"10.1080/14786419.2024.2440515","DOIUrl":null,"url":null,"abstract":"<p><p>Medicinal plants in the high salinity and high alkaline environment might possess some special chemical constituents with new skeleton and high bioactivity. In this work, the main chemical constituents of <i>Limonium sinense,</i> namely flavonoids, were comprehensively studied for the first time. A new flavonoid together with five known compounds were isolated from the whole plants of <i>L. sinense.</i> Their structures were determined by the analysis of comprehensive spectroscopic data. All isolates were evaluated for their anti-inflammatory activity. Compound <b>1</b> exhibited moderate anti-inflammatory activity on NO production with IC<sub>50</sub> value of 20.5 ± 1.3 μM. In addition, 38 flavonoids were identified by UPLC-MS/MS method and 18 reported flavonoids were summarised.</p>","PeriodicalId":18990,"journal":{"name":"Natural Product Research","volume":" ","pages":"1-5"},"PeriodicalIF":1.9000,"publicationDate":"2024-12-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Flavonoids from the whole plants of <i>limonium sinense</i> and their anti-inflammatory activity.\",\"authors\":\"Ban-Ban Li, Shao-Wei Sun, Shuang Miao, Li-Juan Yang, Xin-Yu Meng, Kai-Kai Gong, Shi-Zhou Qi, Jin-Jie Zhang\",\"doi\":\"10.1080/14786419.2024.2440515\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>Medicinal plants in the high salinity and high alkaline environment might possess some special chemical constituents with new skeleton and high bioactivity. In this work, the main chemical constituents of <i>Limonium sinense,</i> namely flavonoids, were comprehensively studied for the first time. A new flavonoid together with five known compounds were isolated from the whole plants of <i>L. sinense.</i> Their structures were determined by the analysis of comprehensive spectroscopic data. All isolates were evaluated for their anti-inflammatory activity. Compound <b>1</b> exhibited moderate anti-inflammatory activity on NO production with IC<sub>50</sub> value of 20.5 ± 1.3 μM. In addition, 38 flavonoids were identified by UPLC-MS/MS method and 18 reported flavonoids were summarised.</p>\",\"PeriodicalId\":18990,\"journal\":{\"name\":\"Natural Product Research\",\"volume\":\" \",\"pages\":\"1-5\"},\"PeriodicalIF\":1.9000,\"publicationDate\":\"2024-12-16\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Natural Product Research\",\"FirstCategoryId\":\"92\",\"ListUrlMain\":\"https://doi.org/10.1080/14786419.2024.2440515\",\"RegionNum\":3,\"RegionCategory\":\"化学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q3\",\"JCRName\":\"CHEMISTRY, APPLIED\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Natural Product Research","FirstCategoryId":"92","ListUrlMain":"https://doi.org/10.1080/14786419.2024.2440515","RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"CHEMISTRY, APPLIED","Score":null,"Total":0}
Flavonoids from the whole plants of limonium sinense and their anti-inflammatory activity.
Medicinal plants in the high salinity and high alkaline environment might possess some special chemical constituents with new skeleton and high bioactivity. In this work, the main chemical constituents of Limonium sinense, namely flavonoids, were comprehensively studied for the first time. A new flavonoid together with five known compounds were isolated from the whole plants of L. sinense. Their structures were determined by the analysis of comprehensive spectroscopic data. All isolates were evaluated for their anti-inflammatory activity. Compound 1 exhibited moderate anti-inflammatory activity on NO production with IC50 value of 20.5 ± 1.3 μM. In addition, 38 flavonoids were identified by UPLC-MS/MS method and 18 reported flavonoids were summarised.
期刊介绍：
The aim of Natural Product Research is to publish important contributions in the field of natural product chemistry. The journal covers all aspects of research in the chemistry and biochemistry of naturally occurring compounds.
The communications include coverage of work on natural substances of land and sea and of plants, microbes and animals. Discussions of structure elucidation, synthesis and experimental biosynthesis of natural products as well as developments of methods in these areas are welcomed in the journal. Finally, research papers in fields on the chemistry-biology boundary, eg. fermentation chemistry, plant tissue culture investigations etc., are accepted into the journal.
Natural Product Research issues will be subtitled either ""Part A - Synthesis and Structure"" or ""Part B - Bioactive Natural Products"". for details on this , see the forthcoming articles section.
All manuscript submissions are subject to initial appraisal by the Editor, and, if found suitable for further consideration, to peer review by independent, anonymous expert referees. All peer review is single blind and submission is online via ScholarOne Manuscripts.
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