IF 10 2区 医学 Q1 ENGINEERING, BIOMEDICAL
Mengqi Li, Zhiliang Gao, Ning Wang, Kanaparedu P C Sekhar, Jingcheng Hao, Jiwei Cui
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引用次数: 0

摘要

本研究报道了组装低免疫原性聚乙二醇纳米粒子(PEG NPs)用于靶向递送治疗药物(即米托蒽醌和咪唑喹啉)和改进光热免疫疗法的方法。这种靶向 PEG NPs 融入了透明质酸靶向分子,是通过金属有机框架模板化而设计的,可避免加速血液清除,延长循环时间,并改善治疗药物在肿瘤部位的蓄积。在激光照射下靶向递送米托蒽醌可诱导肿瘤细胞免疫性死亡,并与咪唑喹啉的收费样受体 7/8 激动剂相结合,引发细胞毒性 T 淋巴细胞的免疫反应,从而消灭肿瘤细胞。此外,该疗法还能诱导肿瘤特异性免疫反应,从而抑制转移性肺肿瘤的生长。这种靶向 PEG NPs 为癌症免疫疗法提供了一种合理的设计。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Targeting of Low-Immunogenic Poly(ethylene glycol) Nanoparticles for Photothermal-Enhanced Immunotherapy.

The assembly of low-immunogenic poly(ethylene glycol) nanoparticles (PEG NPs) for targeted delivery of therapeutics (i.e., mitoxantrone and imidazoquinoline) and improved photothermal-immunotherapy is reported. The targeted PEG NPs incorporating targeting molecules of hyaluronic acid are engineered via the templating of metal-organic frameworks, which can circumvent accelerated blood clearance and exhibit prolonged circulation time as well as improved accumulation of therapeutics at tumor sites. The targeted delivery of mitoxantrone under laser radiation induces immunogenic cell death of tumor cells, which is combined with toll-like receptor 7/8 agonists of imidazoquinoline to trigger immune responses of cytotoxic T lymphocytes for the eradication of tumor cells. Furthermore, the treatment can induce tumor-specific immune responses that inhibit metastatic lung tumor growth. This reported targeted PEG NPs provide a rational design for cancer immunotherapy.

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来源期刊
Advanced Healthcare Materials
Advanced Healthcare Materials 工程技术-生物材料
CiteScore
14.40
自引率
3.00%
发文量
600
审稿时长
1.8 months
期刊介绍: Advanced Healthcare Materials, a distinguished member of the esteemed Advanced portfolio, has been dedicated to disseminating cutting-edge research on materials, devices, and technologies for enhancing human well-being for over ten years. As a comprehensive journal, it encompasses a wide range of disciplines such as biomaterials, biointerfaces, nanomedicine and nanotechnology, tissue engineering, and regenerative medicine.
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