Sept10和sept12在斑马鱼大脑中特异性增殖细胞中表达。

IF 1 4区生物学 Q4 DEVELOPMENTAL BIOLOGY

Gene Expression Patterns Pub Date : 2024-12-12 DOI:10.1016/j.gep.2024.119387

Constantin Berger, Julia Katharina Charlotte Kreß, Frederik Helmprobst

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引用次数: 0

摘要

赛普特蛋白是一组细胞骨架 GTP 结合蛋白，参与细胞分裂、外吞和轴突生长等不同的细胞过程。它们的功能，尤其是在神经系统中的功能尚不清楚。斑马鱼体内有 16 种不同的隔膜蛋白，其中一些在大脑中的表达也有描述。有趣的是，其中几种的表达模式具有高度特异性。在这里，我们描述了 sept10 和 sept12 在发育中的斑马鱼大脑中的表达，并发现它们表现出非常明确的表达模式。有趣的是，它们与神经组织中的一组 PCNA 阳性细胞有重叠，但不是所有增殖的 PCNA 阳性细胞。

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Sept10 and sept12 are expressed in specific proliferating cells in zebrafish brain.

Septins are a group of cytoskeletal GTP binding proteins which are involved in different cellular processes, like cell division, exocytosis and axon growth. Their function, especially in the nervous system, is not clear. In zebrafish 16 different septins are described and for some of them the expression in the brain is described. Interestingly, the expression pattern of several of them is highly specific. Here we describe the expression of sept10 and sept12 in the developing zebrafish brain and found that these show a very defined expression pattern. Interestingly, they show an overlap with a group, but not all proliferating PCNA positive cells in nervous tissue.

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来源期刊

Gene Expression Patterns 生物-发育生物学

CiteScore

2.30

自引率

0.00%

发文量

审稿时长

35 days

期刊介绍： Gene Expression Patterns is devoted to the rapid publication of high quality studies of gene expression in development. Studies using cell culture are also suitable if clearly relevant to development, e.g., analysis of key regulatory genes or of gene sets in the maintenance or differentiation of stem cells. Key areas of interest include: -In-situ studies such as expression patterns of important or interesting genes at all levels, including transcription and protein expression -Temporal studies of large gene sets during development -Transgenic studies to study cell lineage in tissue formation