范式转换：microRNAs与靶基因启动子相互作用，导致转录基因激活或沉默。

IF 3.3 3区生物学 Q3 CELL BIOLOGY

Experimental cell research Pub Date : 2025-01-15 DOI:10.1016/j.yexcr.2024.114372

Neelanjana Sarkar, Arun Kumar

{"title":"范式转换：microRNAs与靶基因启动子相互作用，导致转录基因激活或沉默。","authors":"Neelanjana Sarkar, Arun Kumar","doi":"10.1016/j.yexcr.2024.114372","DOIUrl":null,"url":null,"abstract":"<div><div>MicroRNAs (miRNAs/miRs) are small (18–25 nucleotides in length), endogenous, non-coding RNAs that typically repress gene expression by interacting with the 3′untranslated regions (3′UTRs) of target mRNAs in the cytoplasm. While most of the scientific community still views miRNAs as repressors of gene expression, this review highlights their non-canonical novel role in the nucleus as activators or silencers of target gene transcription through miRNA-promoter interaction. The mechanistic details of the transcriptional role of miRNAs are yet to be elucidated, however, they can be explained by prospective models. In this review, we aim to discuss the different examples of transcriptional regulation by miRNAs and their possible mechanism of action, thereby offering a comprehensive perspective on the role of miRNAs in gene regulation and their importance in health and diseases.</div></div>","PeriodicalId":12227,"journal":{"name":"Experimental cell research","volume":"444 2","pages":"Article 114372"},"PeriodicalIF":3.3000,"publicationDate":"2025-01-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Paradigm shift: microRNAs interact with target gene promoters to cause transcriptional gene activation or silencing\",\"authors\":\"Neelanjana Sarkar, Arun Kumar\",\"doi\":\"10.1016/j.yexcr.2024.114372\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<div><div>MicroRNAs (miRNAs/miRs) are small (18–25 nucleotides in length), endogenous, non-coding RNAs that typically repress gene expression by interacting with the 3′untranslated regions (3′UTRs) of target mRNAs in the cytoplasm. While most of the scientific community still views miRNAs as repressors of gene expression, this review highlights their non-canonical novel role in the nucleus as activators or silencers of target gene transcription through miRNA-promoter interaction. The mechanistic details of the transcriptional role of miRNAs are yet to be elucidated, however, they can be explained by prospective models. In this review, we aim to discuss the different examples of transcriptional regulation by miRNAs and their possible mechanism of action, thereby offering a comprehensive perspective on the role of miRNAs in gene regulation and their importance in health and diseases.</div></div>\",\"PeriodicalId\":12227,\"journal\":{\"name\":\"Experimental cell research\",\"volume\":\"444 2\",\"pages\":\"Article 114372\"},\"PeriodicalIF\":3.3000,\"publicationDate\":\"2025-01-15\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Experimental cell research\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://www.sciencedirect.com/science/article/pii/S0014482724004634\",\"RegionNum\":3,\"RegionCategory\":\"生物学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q3\",\"JCRName\":\"CELL BIOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Experimental cell research","FirstCategoryId":"3","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S0014482724004634","RegionNum":3,"RegionCategory":"生物学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"CELL BIOLOGY","Score":null,"Total":0}

引用次数: 0

摘要

MicroRNAs （miRNAs/miRs）是一种小的（长度为18-25个核苷酸）内源性非编码rna，通常通过与细胞质中靶mrna的3‘非翻译区（3’UTRs）相互作用来抑制基因表达。虽然大多数科学界仍然认为mirna是基因表达的抑制因子，但本综述强调了它们在细胞核中的非规范新作用，即通过mirna -启动子相互作用激活或沉默靶基因转录。mirna转录作用的机制细节尚未阐明。然而，它们可以用前瞻性模型来解释。在这篇综述中，我们旨在讨论mirna转录调控的不同例子及其可能的作用机制，从而提供mirna在基因调控中的作用及其在健康和疾病中的重要性的全面视角。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

查看原文本刊更多论文

Paradigm shift: microRNAs interact with target gene promoters to cause transcriptional gene activation or silencing

MicroRNAs (miRNAs/miRs) are small (18–25 nucleotides in length), endogenous, non-coding RNAs that typically repress gene expression by interacting with the 3′untranslated regions (3′UTRs) of target mRNAs in the cytoplasm. While most of the scientific community still views miRNAs as repressors of gene expression, this review highlights their non-canonical novel role in the nucleus as activators or silencers of target gene transcription through miRNA-promoter interaction. The mechanistic details of the transcriptional role of miRNAs are yet to be elucidated, however, they can be explained by prospective models. In this review, we aim to discuss the different examples of transcriptional regulation by miRNAs and their possible mechanism of action, thereby offering a comprehensive perspective on the role of miRNAs in gene regulation and their importance in health and diseases.

求助全文

通过发布文献求助，成功后即可免费获取论文全文。去求助

来源期刊

Experimental cell research 医学-细胞生物学

CiteScore

7.20

自引率

0.00%

发文量

295

审稿时长

30 days

期刊介绍： Our scope includes but is not limited to areas such as: Chromosome biology; Chromatin and epigenetics; DNA repair; Gene regulation; Nuclear import-export; RNA processing; Non-coding RNAs; Organelle biology; The cytoskeleton; Intracellular trafficking; Cell-cell and cell-matrix interactions; Cell motility and migration; Cell proliferation; Cellular differentiation; Signal transduction; Programmed cell death.