I. V. Zhigacheva, I. F. Rusina, N. I. Krikunova, T. L. Veprintsev, Yu. V. Kuznetsov, M. M. Rasulov
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Biological Activity of Carnitine 2-Ethyl-6-Methyl-3-Hydroxypyridine
The antiradical properties and biological activity of carnitine 2-ethyl-6-methyl-3-hydroxypyridine (СP) are investigated. The drug has strong antiradical activity. In the concentration range 10–6–10–9 M, CP prevents the activation of lipid peroxidation in the membranes of the liver mitochondria of mice incubated in a hypotonic medium. Such incubation causes a change in the fatty acid (FA) composition of the lipid component of mitochondrial membranes: the total relative percentage of 18:2ω6, 18:1ω9, and 22:6ω3 of the main FAs that make up cardiolipin decreased by 8.1%. The introduction of CP in the incubation medium leads not only to the restoration of the pool of these FAs but also to an increase in their content by 15%, which, possibly, contributes to an increase in the efficiency of the mitochondria’s functioning and an increase in the body’s resistance to stress.
期刊介绍：
Russian Journal of Physical Chemistry B: Focus on Physics is a journal that publishes studies in the following areas: elementary physical and chemical processes; structure of chemical compounds, reactivity, effect of external field and environment on chemical transformations; molecular dynamics and molecular organization; dynamics and kinetics of photoand radiation-induced processes; mechanism of chemical reactions in gas and condensed phases and at interfaces; chain and thermal processes of ignition, combustion and detonation in gases, two-phase and condensed systems; shock waves; new physical methods of examining chemical reactions; and biological processes in chemical physics.
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