{"title":"dna结合缺陷Hand2与Tcf3a二聚体控制斑马鱼心脏发生。","authors":"","doi":"10.1038/s44161-024-00589-8","DOIUrl":null,"url":null,"abstract":"The bHLH transcription factor Hand2 positively regulates pdgfra expression to promote early cardiogenesis in zebrafish. Hand2 can function in this process independently of direct DNA binding by interacting with Tcf3a, another bHLH transcription factor.","PeriodicalId":74245,"journal":{"name":"Nature cardiovascular research","volume":"3 12","pages":"1383-1384"},"PeriodicalIF":9.4000,"publicationDate":"2024-12-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"DNA-binding-deficient Hand2 dimerizes with Tcf3a to control zebrafish cardiogenesis\",\"authors\":\"\",\"doi\":\"10.1038/s44161-024-00589-8\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"The bHLH transcription factor Hand2 positively regulates pdgfra expression to promote early cardiogenesis in zebrafish. Hand2 can function in this process independently of direct DNA binding by interacting with Tcf3a, another bHLH transcription factor.\",\"PeriodicalId\":74245,\"journal\":{\"name\":\"Nature cardiovascular research\",\"volume\":\"3 12\",\"pages\":\"1383-1384\"},\"PeriodicalIF\":9.4000,\"publicationDate\":\"2024-12-10\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Nature cardiovascular research\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://www.nature.com/articles/s44161-024-00589-8\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"CARDIAC & CARDIOVASCULAR SYSTEMS\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Nature cardiovascular research","FirstCategoryId":"1085","ListUrlMain":"https://www.nature.com/articles/s44161-024-00589-8","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"CARDIAC & CARDIOVASCULAR SYSTEMS","Score":null,"Total":0}
DNA-binding-deficient Hand2 dimerizes with Tcf3a to control zebrafish cardiogenesis
The bHLH transcription factor Hand2 positively regulates pdgfra expression to promote early cardiogenesis in zebrafish. Hand2 can function in this process independently of direct DNA binding by interacting with Tcf3a, another bHLH transcription factor.
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