杜匹单抗成功治疗特应性儿童的寻常型天疱疮伴食管累及。

IF 1.2 4区医学 Q3 DERMATOLOGY

Pediatric Dermatology Pub Date : 2024-12-11 DOI:10.1111/pde.15779

Sonora Yun, Blair A Jenkins, Margaret E Scollan, Amy R Defelice, Kristin M Leiferman, Joshua D Milner, Christine T Lauren

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引用次数: 0

摘要

我们报告的情况下，一个3岁的男孩被诊断为儿童期寻常性天疱疮已经发展为口腔病变，胃肠道症状与食道受累，并未能茁壮成长。血清总IgE水平明显升高，外周血嗜酸性粒细胞增多。该天疱疮对常规治疗难以抵抗，基于Th2免疫偏差的共存特征，他接受了杜匹单抗治疗，自开始治疗以来临床持续改善。该病例说明了在儿童期识别寻常型天疱疮的重要性，考虑dupilumab治疗，以及早期天疱疮自身抗体、Th2炎症和特应性疾病之间潜在的病理生理联系。

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Pemphigus Vulgaris With Esophageal Involvement in an Atopic Child Successfully Treated With Dupilumab.

We report the case of a 3-year-old boy who was diagnosed with childhood pemphigus vulgaris having developed oral lesions, gastrointestinal symptoms with esophageal involvement, and failure to thrive. He had a markedly increased total serum IgE level and peripheral blood eosinophilia. The pemphigus was recalcitrant to conventional therapies and, based on the coexisting characteristics of Th2 immune deviation, he was treated with dupilumab and has had sustained clinical improvement since starting treatment. The case illustrates the importance of recognizing pemphigus vulgaris in childhood, considerations for dupilumab therapy, and a potential pathophysiological links between pemphigus autoantibodies in early life, Th2 inflammation, and atopic disorder.

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来源期刊

Pediatric Dermatology 医学-皮肤病学

CiteScore

3.20

自引率

6.70%

发文量

269

审稿时长

1 months

期刊介绍： Pediatric Dermatology answers the need for new ideas and strategies for today''s pediatrician or dermatologist. As a teaching vehicle, the Journal is still unsurpassed and it will continue to present the latest on topics such as hemangiomas, atopic dermatitis, rare and unusual presentations of childhood diseases, neonatal medicine, and therapeutic advances. As important progress is made in any area involving infants and children, Pediatric Dermatology is there to publish the findings.