Amir Hossein Lame-Jouybari, Mohammad Salar Fahami, Mahla Sadat Hosseini, Maryam Moradpour, Ali Hojati, Mahdieh Abbasalizad-Farhangi
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引用次数: 0
摘要
背景：端粒维持染色体的稳定性并标志着细胞的衰老，它们随着年龄的增长而缩短，损害了基因组的稳定性。目的：本研究的目的是对现有证据进行荟萃分析，以评估孕妇妊娠体重指数（BMI）与儿童端粒长度（TL）的关系。数据来源：Web of Science、Scopus和PubMed数据库从创建到2023年8月27日进行了系统检索，以获取相关的观察性研究。数据提取：随机效应荟萃分析对符合条件的研究进行，利用报告的β-系数，调查暴露与感兴趣的结果之间的线性关系。采用Cochran’s Q检验和I2统计来评估异质性。数据分析：孕产妇妊娠BMI与儿童TL存在显著相关性(32项研究，合并效应量[ES]: -0.04；95% CI: -0.06 ~ -0.01；结论：孕妇孕前BMI与婴儿TL呈负相关，在正常至肥胖BMI范围内明显。这强调了孕前母亲体重状况作为子代体重的决定因素的重要性。CRD42023466425。
Association Between Maternal Prepregnancy and Pregnancy Body Mass Index and Children's Telomere Length: A Systematic Review and Meta-analysis.
Context: Telomeres maintain chromosome stability and mark cellular aging, and their shortening with age compromises genomic stability.
Objective: The purpose of this study was to conduct a meta-analysis of existing evidence to evaluate the relationship between the maternal pregnancy body mass index (BMI) and children's telomere length (TL).
Data source: Web of Science, Scopus, and PubMed databases were systematically searched from their inception to August 27, 2023, for pertinent observational studies.
Data extraction: The random-effects meta-analysis was conducted on eligible studies that investigated the linear relationship between exposure and the outcomes of interest, utilizing the reported β-coefficient. Cochran's Q test and I2 statistics were used to assess heterogeneity.
Data analysis: A significant association was observed between maternal pregnancy BMI and children's TL (32 studies, pooled effect size [ES]: -0.04; 95% CI: -0.06 to -0.01; I2 = 47.51%, P < .001) and maternal prepregnancy BMI and children's TL at birth (16 studies; pooled ES: -0.05; 95% CI: -0.08 to -0.02; I2 = 53.49%, P < .001).
Conclusion: The findings indicate an inverse association between maternal prepregnancy BMI and TL in infants, which is evident within the normal to obese BMI range. This underscores the significance of maternal weight status before pregnancy as a determinant of offspring TL.
期刊介绍：
Nutrition Reviews is a highly cited, monthly, international, peer-reviewed journal that specializes in the publication of authoritative and critical literature reviews on current and emerging topics in nutrition science, food science, clinical nutrition, and nutrition policy. Readers of Nutrition Reviews include nutrition scientists, biomedical researchers, clinical and dietetic practitioners, and advanced students of nutrition.
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