利用金纳米材料对抗病毒性疾病的黄金治疗方法。

IF 1.6 4区 医学 Q4 BIOCHEMICAL RESEARCH METHODS
Jasmine, Neelam Singh, Dheeraj Nagpal, Sanchit Puniani, Puneet Gupta
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引用次数: 0

摘要

金纳米颗粒(AuNPs)由于其独特的性能和表面修饰能力,已成为一系列生物医学应用的有前途的载体。aunp具有内在的抗病毒特性,因为它们能够通过使抗病毒药物更稳定和可溶来增强药物分布,从而确保更多的药物到达预定部位。通过表面变化,AuNPs可以直接与病毒颗粒或感染细胞结合,提高治疗效率,减少副作用。AuNPs有效地破坏细胞膜并阻碍病毒在宿主细胞内的繁殖。此外,由于它们的表面积体积比大,这使得许多官能团能够连接起来,改善了与病毒颗粒的相互作用,并停止了它们的增殖。通过改变尺寸和形态或与其他抗病毒药物偶联,AuNPs可以排列其协同抗病毒活性。因此,AuNP偶联疗法的发展为解决对几种药物耐药感染的新型抗病毒治疗的需求提供了一条有希望的途径。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Golden Therapeutic Approach to Combat Viral Diseases Using Gold Nanomaterials.

Gold nanoparticles (AuNPs), due to their unique properties and surface modification abilities, have become a promising carrier for a range of biomedical applications. AuNPs have intrinsic antiviral characteristics because of their capacity to enhance drug distribution by making antiviral medications more stable and soluble, which assures that higher quantities reach the intended site. Through surface changes, AuNPs can bind directly to viral particles or infected cells, increasing therapeutic efficiency and reducing side effects. AuNPs efficiently damage cell membranes and hinder viral reproduction within a host cell. Furthermore, because of their large surface area-to-volume ratio, which enables many functional groups to connect, improving interaction with virus particles and ceasing their multiplication. By altering dimensions and morphology or conjugating it with additional antiviral drugs, AuNPs can array their synergistic antiviral activity. Thus, the development of AuNP conjugated therapy presents a promising avenue to address the demand for novel anti-viral therapeutics against infections resistant to several drugs.

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来源期刊
Assay and drug development technologies
Assay and drug development technologies 医学-生化研究方法
CiteScore
3.60
自引率
0.00%
发文量
33
审稿时长
>12 weeks
期刊介绍: ASSAY and Drug Development Technologies provides access to novel techniques and robust tools that enable critical advances in early-stage screening. This research published in the Journal leads to important therapeutics and platforms for drug discovery and development. This reputable peer-reviewed journal features original papers application-oriented technology reviews, topical issues on novel and burgeoning areas of research, and reports in methodology and technology application. ASSAY and Drug Development Technologies coverage includes: -Assay design, target development, and high-throughput technologies- Hit to Lead optimization and medicinal chemistry through preclinical candidate selection- Lab automation, sample management, bioinformatics, data mining, virtual screening, and data analysis- Approaches to assays configured for gene families, inherited, and infectious diseases- Assays and strategies for adapting model organisms to drug discovery- The use of stem cells as models of disease- Translation of phenotypic outputs to target identification- Exploration and mechanistic studies of the technical basis for assay and screening artifacts
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