阻碍感染：解旋酶棘轮作为噬菌体感应机制出现

IF 20.6 1区医学 Q1 MICROBIOLOGY

Cell host & microbe Pub Date : 2024-12-11 DOI:10.1016/j.chom.2024.11.009

Zhifeng Zeng, Wenyuan Han

引用次数: 0

摘要

对病原体的感知是任何免疫反应的第一步。最近发表在Cell上的一篇论文揭示了细菌Hachiman抗噬菌体防御系统部署一个解旋酶亚基，通过3 ' DNA识别和随后的结构域旋转来感知噬菌体的入侵，从而激活核酸酶。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

查看原文本刊更多论文

HAMpering infection: Helicase ratcheting emerges as a phage-sensing mechanism

The sensing of pathogens is the first step for any immune response. A recent paper in Cell reveals that the bacterial Hachiman anti-phage defense system deploys a helicase subunit to sense phage invasion via 3′ DNA recognition and subsequent domain rotation to enable nuclease activation.

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来源期刊

Cell host & microbe 生物-微生物学

CiteScore

45.10

自引率

1.70%

发文量

201

审稿时长

4-8 weeks

期刊介绍： Cell Host & Microbe is a scientific journal that was launched in March 2007. The journal aims to provide a platform for scientists to exchange ideas and concepts related to the study of microbes and their interaction with host organisms at a molecular, cellular, and immune level. It publishes novel findings on a wide range of microorganisms including bacteria, fungi, parasites, and viruses. The journal focuses on the interface between the microbe and its host, whether the host is a vertebrate, invertebrate, or plant, and whether the microbe is pathogenic, non-pathogenic, or commensal. The integrated study of microbes and their interactions with each other, their host, and the cellular environment they inhabit is a unifying theme of the journal. The published work in Cell Host & Microbe is expected to be of exceptional significance within its field and also of interest to researchers in other areas. In addition to primary research articles, the journal features expert analysis, commentary, and reviews on current topics of interest in the field.