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IF 4.9 2区医学 Q1 CLINICAL NEUROLOGY

Journal of affective disorders Pub Date : 2024-12-07 DOI:10.1016/j.jad.2024.11.082

Xiujuan Li, Mingyi Dong, Wenjing Xia, Can Huang, Taoyun Zheng, Xinhong Zhu

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引用次数: 0

摘要

研究背景方法：本研究从中国健康与退休纵向研究（CHARLS）中纳入了1921名基线年龄≥45岁的个体。测量指标包括ACEs、AAEs、抑郁症状评分、健康相关因素和人口特征。AL变化通过第3波（2015年）与第1波（2011年）之间AL得分的差异进行评估：与持续的低轨迹相比，2 次或 2 次以上 ACE（OR 1.78，95 % CI 1.28-2.46）、2 次或 2 次以上 AAE（OR 1.82，95 % CI 1.26-2.64）、代谢性 AL 随时间下降（OR 0.63，95 % CI 0.46-0.86）、炎症性 AL 随时间增加（OR 1.60，95 % CI 1.07-2.37）和肾脏 AL 随时间减少（OR 1.38，95 % CI 1.01-1.87）与中低度抑郁症状轨迹相关。此外，2 次或更多的 ACE（OR 1.48，95 % CI 1.10-2.00）、2 次或更多的 AAE（OR 1.85，95 % CI 1.32-2.60）、代谢性 AL 随时间推移而降低（OR 0.75，95 % CI 0.57-1.00）、炎症性 AL 随时间推移而升高（OR 1.69，95 % CI 1.19-2.42）与中度抑郁症状高发轨迹相关：结论：经历更多的 ACE 和 AAE 与更高的抑郁症状轨迹相关。此外，代谢性AL随时间推移而降低的参与者抑郁症状轨迹较低，而炎症性AL随时间推移而增加和肾性AL随时间推移而降低的参与者抑郁症状轨迹较差。这些发现凸显了压力对心理健康结果造成的生理损害。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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The association between adverse experiences and longitudinal allostatic load changes with the depression symptoms trajectories in middle-aged and older adults in China: A longitudinal study.

Background: This study investigated the associations between adverse childhood experiences (ACEs), adverse adulthood experiences (AAEs), allostatic load (AL) changes, and later depression symptoms trajectories in middle-aged and older Chinese longitudinally.

Methods: 1921 individuals aged ≥45 years at baseline were included from the China Health and Retirement Longitudinal Study (CHARLS). Measures included ACEs, AAEs, depression symptoms scores, health-related factors, and demographic characteristics. AL changes were assessed by the difference in AL scores between wave 3 (2015) and wave 1(2011).

Results: Compared to consistently low trajectory, 2 or more ACEs (OR 1.78, 95 % CI 1.28-2.46), 2 or more AAEs (OR 1.82, 95 % CI 1.26-2.64), decreasing metabolic AL over time (OR 0.63, 95 % CI 0.46-0.86), increasing inflammatory AL over time (OR 1.60, 95 % CI 1.07-2.37), and decreasing renal AL over time (OR 1.38, 95 % CI 1.01-1.87) were associated with the low-moderate depression symptoms trajectory. Furthermore, 2 or more ACEs (OR 1.48, 95 % CI 1.10-2.00), 2 or more AAEs (OR 1.85, 95 % CI 1.32-2.60), decreasing metabolic AL over time (OR 0.75, 95 % CI 0.57-1.00), increasing inflammatory AL over time (OR 1.69, 95 % CI 1.19-2.42) were associated with the high-moderate depression symptoms trajectory.

Conclusion: Experiencing more ACEs and AAEs was associated with higher depression symptoms trajectories. Moreover, participants with decreasing metabolic AL over time showed a low depression symptoms trajectory, while those with increasing inflammatory AL over time and decreasing renal AL over time showed a worse depression symptoms trajectory. These findings highlighted the physiological damage caused by stress on mental health outcomes.

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来源期刊

Journal of affective disorders 医学-精神病学

CiteScore

10.90

自引率

6.10%

发文量

1319

审稿时长

9.3 weeks

期刊介绍： The Journal of Affective Disorders publishes papers concerned with affective disorders in the widest sense: depression, mania, mood spectrum, emotions and personality, anxiety and stress. It is interdisciplinary and aims to bring together different approaches for a diverse readership. Top quality papers will be accepted dealing with any aspect of affective disorders, including neuroimaging, cognitive neurosciences, genetics, molecular biology, experimental and clinical neurosciences, pharmacology, neuroimmunoendocrinology, intervention and treatment trials.