microRNA-138-5p通过Sorbin和SH3结构域蛋白2在乳腺癌中的作用研究

IF 3.2 3区医学 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY

Journal of Biochemical and Molecular Toxicology Pub Date : 2024-12-10 DOI:10.1002/jbt.70081

LiGong Zhang, Chao Zhu, Chenxu Guo, FaXiang Yin, Qiang Xie, Min Tao

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引用次数: 0

摘要

乳腺癌（BRCA）是全球妇女健康的主要威胁之一。本研究重点研究sorbin、SH3 domain containing protein 2 （SORBS2）蛋白和microRNA-138-5p在BRCA进展中的作用，分析其对癌细胞增殖、细胞周期和迁移能力的调控作用。利用生物信息学工具和实验方法，研究发现SORBS2在BRCA中普遍低表达。此外，研究表明microRNA-138-5p可通过抑制SORBS2表达显著抑制肿瘤生长，为BRCA治疗提供新的分子靶点。

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Study on the Role of microRNA-138-5p Through Sorbin and SH3 Domain-Containing Protein 2 in Breast Cancer

Breast cancer (BRCA) is one of the major threats to women's health worldwide. This study focuses on the roles of sorbin and SH3 domain-containing protein 2 (SORBS2) protein and microRNA-138-5p in the progression of BRCA, analyzing their regulatory effects on cancer cell proliferation, cell cycle, and migration ability. Using bioinformatics tools and experimental methods, the study found that SORBS2 is commonly underexpressed in BRCA. Additionally, it demonstrated that microRNA-138-5p can significantly inhibit tumor growth by suppressing SORBS2 expression, providing new molecular targets for BRCA treatment.

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来源期刊

Journal of Biochemical and Molecular Toxicology 生物-毒理学

CiteScore

5.80

自引率

2.80%

发文量

277

审稿时长

6-12 weeks

期刊介绍： The Journal of Biochemical and Molecular Toxicology is an international journal that contains original research papers, rapid communications, mini-reviews, and book reviews, all focusing on the molecular mechanisms of action and detoxication of exogenous and endogenous chemicals and toxic agents. The scope includes effects on the organism at all stages of development, on organ systems, tissues, and cells as well as on enzymes, receptors, hormones, and genes. The biochemical and molecular aspects of uptake, transport, storage, excretion, lactivation and detoxication of drugs, agricultural, industrial and environmental chemicals, natural products and food additives are all subjects suitable for publication. Of particular interest are aspects of molecular biology related to biochemical toxicology. These include studies of the expression of genes related to detoxication and activation enzymes, toxicants with modes of action involving effects on nucleic acids, gene expression and protein synthesis, and the toxicity of products derived from biotechnology.