棕榈酸熔体中卡马西平II型的模板定向结晶——了解卡马西平†机械诱导多态性的关键

IF 2.6 3区化学 Q2 CHEMISTRY, MULTIDISCIPLINARY

CrystEngComm Pub Date : 2024-11-15 DOI:10.1039/D4CE00906A

Evgeniy A. Losev, Daria Ya. Zheltikova, Valeri A. Drebushchak and Elena V. Boldyreva

{"title":"棕榈酸熔体中卡马西平II型的模板定向结晶——了解卡马西平†机械诱导多态性的关键","authors":"Evgeniy A. Losev, Daria Ya. Zheltikova, Valeri A. Drebushchak and Elena V. Boldyreva","doi":"10.1039/D4CE00906A","DOIUrl":null,"url":null,"abstract":"<p >Heating a single crystal of carbamazepine (III) (the thermodynamically stable form) in contact with solid palmitic acid resulted in the melting of palmitic acid and the growth of the crystals of carbamazepine (II) (the least stable polymorph) at the interface “carbamazepine (III) crystal–palmitic acid melt”. The study suggests a possible mechanism of the transformation of carbamazepine (III) into carbamazepine (II) on mechanical treatment with palmitic acid as an additive.</p>","PeriodicalId":70,"journal":{"name":"CrystEngComm","volume":" 48","pages":" 6796-6804"},"PeriodicalIF":2.6000,"publicationDate":"2024-11-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Template-directed crystallization of carbamazepine form II from palmitic acid melt – a key to understand mechanically-induced polymorphism of carbamazepine†\",\"authors\":\"Evgeniy A. Losev, Daria Ya. Zheltikova, Valeri A. Drebushchak and Elena V. Boldyreva\",\"doi\":\"10.1039/D4CE00906A\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p >Heating a single crystal of carbamazepine (III) (the thermodynamically stable form) in contact with solid palmitic acid resulted in the melting of palmitic acid and the growth of the crystals of carbamazepine (II) (the least stable polymorph) at the interface “carbamazepine (III) crystal–palmitic acid melt”. The study suggests a possible mechanism of the transformation of carbamazepine (III) into carbamazepine (II) on mechanical treatment with palmitic acid as an additive.</p>\",\"PeriodicalId\":70,\"journal\":{\"name\":\"CrystEngComm\",\"volume\":\" 48\",\"pages\":\" 6796-6804\"},\"PeriodicalIF\":2.6000,\"publicationDate\":\"2024-11-15\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"CrystEngComm\",\"FirstCategoryId\":\"92\",\"ListUrlMain\":\"https://pubs.rsc.org/en/content/articlelanding/2024/ce/d4ce00906a\",\"RegionNum\":3,\"RegionCategory\":\"化学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q2\",\"JCRName\":\"CHEMISTRY, MULTIDISCIPLINARY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"CrystEngComm","FirstCategoryId":"92","ListUrlMain":"https://pubs.rsc.org/en/content/articlelanding/2024/ce/d4ce00906a","RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"CHEMISTRY, MULTIDISCIPLINARY","Score":null,"Total":0}

引用次数: 0

摘要

加热卡马西平（III）单晶（热力学稳定的形式）与固体棕榈酸接触，导致棕榈酸熔化，卡马西平（II）晶体（最不稳定的多晶）在“卡马西平（III）晶体-棕榈酸熔体”界面生长。本研究提出了卡马西平（III）在棕榈酸作为添加剂的机械处理下转化为卡马西平（II）的可能机理。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Template-directed crystallization of carbamazepine form II from palmitic acid melt – a key to understand mechanically-induced polymorphism of carbamazepine†

查看原文本刊更多论文

Template-directed crystallization of carbamazepine form II from palmitic acid melt – a key to understand mechanically-induced polymorphism of carbamazepine†

Heating a single crystal of carbamazepine (III) (the thermodynamically stable form) in contact with solid palmitic acid resulted in the melting of palmitic acid and the growth of the crystals of carbamazepine (II) (the least stable polymorph) at the interface “carbamazepine (III) crystal–palmitic acid melt”. The study suggests a possible mechanism of the transformation of carbamazepine (III) into carbamazepine (II) on mechanical treatment with palmitic acid as an additive.

求助全文

通过发布文献求助，成功后即可免费获取论文全文。去求助

来源期刊