莲胚中苯基异喹啉类生物碱及其抗氧化作用。

IF 2.5 3区医学 Q3 CHEMISTRY, MEDICINAL

Fitoterapia Pub Date : 2025-01-01 Epub Date: 2024-12-03 DOI:10.1016/j.fitote.2024.106330

Zhanrong Zhou, Xin Wang, Hongqing Wang, Hongjie Shao, Junhua Sun, Ruoyun Chen, Jie Kang

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引用次数: 0

摘要

从莲胚中分离到7个苯基异喹啉类生物碱，包括3个新化合物（1-3）和4个已知化合物（4-7）。通过UV、IR、hresms、1D和2D NMR、ECD光谱以及旋光性对其结构进行了表征。对所有化合物进行抗氧化活性测定。化合物1 ~ 7对Fe2+诱导的小鼠肝微粒体脂质过氧化的抑制率分别为76.1、75.7、60.0、82.9、75.5、83.8和85.3 %。

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Benzylisoquinoline alkaloids from the embryo of Nelumbo nucifera and their antioxidant effects.

Seven benzylisoquinoline alkaloids, including three new (1-3) and four known compounds (4-7), were isolated from the embryo of Nelumbo nucifera (Plumula Nelumbinis). Their structures were elucidated by UV, IR, HRESIMS, 1D and 2D NMR, and ECD spectra, as well as optical rotations. All compounds were tested for the antioxidant activity. Compounds 1-7 prevented Fe²⁺ induced lipid peroxidation in mouse liver microsomes, with the inhibitory rates of 76.1, 75.7, 60.0, 82.9, 75.5, 83.8 and 85.3 %, respectively.

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来源期刊

Fitoterapia 医学-药学

CiteScore

5.80

自引率

2.90%

发文量

198

审稿时长

1.5 months

期刊介绍： Fitoterapia is a Journal dedicated to medicinal plants and to bioactive natural products of plant origin. It publishes original contributions in seven major areas: 1. Characterization of active ingredients of medicinal plants 2. Development of standardization method for bioactive plant extracts and natural products 3. Identification of bioactivity in plant extracts 4. Identification of targets and mechanism of activity of plant extracts 5. Production and genomic characterization of medicinal plants biomass 6. Chemistry and biochemistry of bioactive natural products of plant origin 7. Critical reviews of the historical, clinical and legal status of medicinal plants, and accounts on topical issues.