从黄芪茎叶中提取新的黄酮类苷。

IF 2.5 3区医学 Q3 CHEMISTRY, MEDICINAL

Fitoterapia Pub Date : 2025-01-01 Epub Date: 2024-12-03 DOI:10.1016/j.fitote.2024.106321

Jin-Yan Tan, Jia-Xin Zhao, Yun Zang, Pei Li, Si-Qi Yang, Xiao-Mao Li, Ying-Li Wang, Yan-Gang Cheng

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引用次数: 0

摘要

黄芪是一种著名的传统医药和食品，因其根源而被广泛研究。然而，相对而言，很少有人注意到它的茎和叶。本研究成功从黄芪茎叶中分离鉴定了3个新的黄酮类苷（1-3）和8个已知的类似物（4-11）。值得注意的是，化合物10对lps诱导的BV2细胞具有显著的抗炎活性，IC50值为1.11 ± 0.04 μM。这些发现强调黄酮类化合物是黄芪茎叶中存在的关键生物活性成分。

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New flavonoid glycosides from the stems and leaves of Astragalus membranaceus.

Astragalus membranaceus, a well-known traditional medicine and food, has been extensively studied for its roots. However, comparatively little attention has been paid to its stems and leaves. In this study, we successfully isolated and identified three new flavonoid glycosides (1-3), and eight known analogues (4-11) from the stems and leaves of A. membranaceus. Notably, compound 10 exhibited significant anti-inflammatory activities in LPS-induced BV2 cells, with IC₅₀ value of 1.11 ± 0.04 μM. These findings highlight flavonoids as the key bioactive components present in the stems and leaves of A. membranaceus.

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来源期刊

Fitoterapia 医学-药学

CiteScore

5.80

自引率

2.90%

发文量

198

审稿时长

1.5 months

期刊介绍： Fitoterapia is a Journal dedicated to medicinal plants and to bioactive natural products of plant origin. It publishes original contributions in seven major areas: 1. Characterization of active ingredients of medicinal plants 2. Development of standardization method for bioactive plant extracts and natural products 3. Identification of bioactivity in plant extracts 4. Identification of targets and mechanism of activity of plant extracts 5. Production and genomic characterization of medicinal plants biomass 6. Chemistry and biochemistry of bioactive natural products of plant origin 7. Critical reviews of the historical, clinical and legal status of medicinal plants, and accounts on topical issues.