扩展淀粉样变诊断：18F-FDG PET/CT和99mTc-PYP SPECT/CT显示腹膜AL淀粉样变1例。

IF 9.6 3区医学 Q1 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING

Clinical Nuclear Medicine Pub Date : 2025-03-01 Epub Date: 2024-12-06 DOI:10.1097/RLU.0000000000005603

Dilsat Fırat Arslan, Ekin Inal, Emine Göknur Isik, Yasemin Sanli

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引用次数: 0

摘要

摘要：我们报告一例继发于免疫球蛋白轻链淀粉样变性（AL淀粉样变性）的全身性淀粉样变性，其18F-FDG PET/CT和99mTc-PYP显像显示淀粉样蛋白沉积在腹膜、网膜和肠系膜。AL淀粉样变的特点是克隆浆细胞增殖，免疫球蛋白轻链的产生和细胞外积累增加，导致器官功能障碍。尽管AL淀粉样变可以影响胃肠道系统，但很少观察到累及腹膜。PET/CT和SPECT/CT图像显示受累器官示踪剂摄取中度至轻度增加。

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Extending Amyloidosis Diagnosis: A Rare Case of Peritoneal AL Amyloidosis Revealed by 18 F-FDG PET/CT and 99m Tc-PYP SPECT/CT.

Abstract: We present a case with systemic amyloidosis secondary to immunoglobulin light-chain amyloidosis (AL amyloidosis), which 18 F-FDG PET/CT and 99m Tc-PYP scintigraphy revealed amyloid deposition in the peritoneum, omentum, and mesentery. AL amyloidosis is characterized by the proliferation of clonal plasma cells and increased production and extracellular accumulation of immunoglobulin light chains, leading to organ malfunction. Even though AL amyloidosis can affect the gastrointestinal system, peritoneal involvement is rarely observed. PET/CT and SPECT/CT images showed moderate to slightly increased tracer uptake in affected organs.

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来源期刊

Clinical Nuclear Medicine 医学-核医学

CiteScore

2.90

自引率

31.10%

发文量

1113

审稿时长

2 months

期刊介绍： Clinical Nuclear Medicine is a comprehensive and current resource for professionals in the field of nuclear medicine. It caters to both generalists and specialists, offering valuable insights on how to effectively apply nuclear medicine techniques in various clinical scenarios. With a focus on timely dissemination of information, this journal covers the latest developments that impact all aspects of the specialty. Geared towards practitioners, Clinical Nuclear Medicine is the ultimate practice-oriented publication in the field of nuclear imaging. Its informative articles are complemented by numerous illustrations that demonstrate how physicians can seamlessly integrate the knowledge gained into their everyday practice.