利用斑马鱼模型推进放射生物学：辐射暴露研究的机制、应用和未来展望。

IF 7.7 2区环境科学与生态学 Q1 ENVIRONMENTAL SCIENCES

Environmental Research Pub Date : 2025-02-01 DOI:10.1016/j.envres.2024.120504

Ting Xu , Fan Liu , Jiaxuan He , Peiye Xu , Junying Qu , Hanbing Wang , Jinghui Yue , Qinsi Yang , Wei Wu , Guoming Zeng , Da Sun , Xia Chen

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引用次数: 0

摘要

电离辐射对人类健康和社会稳定构成重大风险。为了有效地分析IR的机制并加强保护策略，开发更复杂的动物模型势在必行。斑马鱼基因组与人类高度同源，具有全身光学可视化和高通量筛选的能力，是红外研究的宝贵模型。本文综述了利用斑马鱼作为IR研究的模式生物的好处，重点介绍了最近的进展和应用。它全面概述了在斑马鱼中建立IR模型的方法，解决了当前的挑战，并讨论了未来的发展趋势。本文为阐明IR损伤机制和制定有效的治疗策略提供理论支持。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Leveraging zebrafish models for advancing radiobiology: Mechanisms, applications, and future prospects in radiation exposure research

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Leveraging zebrafish models for advancing radiobiology: Mechanisms, applications, and future prospects in radiation exposure research

Ionizing radiation (IR) represents a significant risk to human health and societal stability. To effectively analyze the mechanisms of IR and enhance protective strategies, the development of more sophisticated animal models is imperative. The zebrafish, with its high degree of genomic homology to humans and the capacity for whole-body optical visualization and high-throughput screening, represents an invaluable model for the study of IR. This review examines the benefits of utilizing zebrafish as a model organism for research on IR, emphasizing recent advancements and applications. It presents a comprehensive overview of the methodologies for establishing IR models in zebrafish, addresses current challenges, and discusses future development trends. This paper provide theoretical support for elucidating the mechanisms of IR injury and developing effective treatment strategies.

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来源期刊

Environmental Research 环境科学-公共卫生、环境卫生与职业卫生

CiteScore

12.60

自引率

8.40%

发文量

2480

审稿时长

4.7 months

期刊介绍： The Environmental Research journal presents a broad range of interdisciplinary research, focused on addressing worldwide environmental concerns and featuring innovative findings. Our publication strives to explore relevant anthropogenic issues across various environmental sectors, showcasing practical applications in real-life settings.