为医学治疗创造新的蛋白质：短标题：设计治疗性蛋白质。

IF 2.5 3区医学 Q1 MEDICINE, GENERAL & INTERNAL

American Journal of Medicine Pub Date : 2024-12-02 DOI:10.1016/j.amjmed.2024.11.023

Edward J Goetzl

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引用次数: 0

摘要

人工智能衍生的计算设计方法的最新应用允许从头创造自然界中不存在的蛋白质，但对人体细胞和器官系统具有强大的影响。这些快速的程序还允许一步蛋白质修饰，优化功能，效力，稳定性，抗生物降解，细胞和组织分布以及生物半衰期。迄今为止产生的这类蛋白质包括细胞因子、抗体、细胞死亡蛋白抑制剂和生长因子和病毒的细胞外受体拮抗剂。新设计的蛋白质具有广泛的医学诊断和治疗潜力，以及改变人类细胞许多正常活动的能力。

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Creating New Proteins for Medical Therapeutics.

Recent applications of artificial intelligence-derived methods of computational design have permitted de novo creation of proteins that do not exist in nature but have potent effects on human cells and organ systems. These rapid procedures also allow in 1 step protein modifications that optimize function, potency, stability, resistance to biodegradation, cellular and tissue distribution and biological half-time. Such proteins generated to date include cytokines, antibodies, inhibitors of cell death proteins and antagonists of extracellular receptors for growth factors and viruses. Newly designed proteins have broad medical diagnostic and therapeutic potentials, as well as the capacity to alter many normal activities of human cells.

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来源期刊

American Journal of Medicine 医学-医学：内科

CiteScore

6.30

自引率

3.40%

发文量

449

审稿时长

9 days

期刊介绍： The American Journal of Medicine - "The Green Journal" - publishes original clinical research of interest to physicians in internal medicine, both in academia and community-based practice. AJM is the official journal of the Alliance for Academic Internal Medicine, a prestigious group comprising internal medicine department chairs at more than 125 medical schools across the U.S. Each issue carries useful reviews as well as seminal articles of immediate interest to the practicing physician, including peer-reviewed, original scientific studies that have direct clinical significance and position papers on health care issues, medical education, and public policy.