microRNA与高血压。

IF 6.9 1区医学 Q1 PERIPHERAL VASCULAR DISEASE

Hypertension Pub Date : 2025-02-01 Epub Date: 2024-12-05 DOI:10.1161/HYPERTENSIONAHA.124.21728

Lishu He, Yong Liu, Michael E Widlansky, Alison J Kriegel, Qiongzi Qiu, Mingyu Liang

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引用次数: 0

摘要

几种微小rna （miRNAs）通过调节血管、肾脏和其他生理机制强烈影响血压和高血压的发生。此外，mirna可能参与血压的遗传调控。未来的研究应侧重于研究具有强大生理作用的miRNA，了解细胞环境依赖机制赋予miRNA作用的特异性，并将miRNA作为强大的调节剂整合到调节血压和高血压发展的分子系统中。

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microRNA and Hypertension.

Several microRNAs (miRNAs) strongly influence blood pressure and the development of hypertension by modulating vascular, renal, and other physiological mechanisms. In addition, miRNAs may contribute to the genetic regulation of blood pressure. Future research should focus on investigating select miRNAs with potent physiological effects, understanding cellular context-dependent mechanisms conferring specificity to miRNA action, and integrating miRNAs as powerful modulators into the molecular system that underlies the regulation of blood pressure and the development of hypertension.

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来源期刊

Hypertension 医学-外周血管病

CiteScore

15.90

自引率

4.80%

发文量

1006

审稿时长

1 months

期刊介绍： Hypertension presents top-tier articles on high blood pressure in each monthly release. These articles delve into basic science, clinical treatment, and prevention of hypertension and associated cardiovascular, metabolic, and renal conditions. Renowned for their lasting significance, these papers contribute to advancing our understanding and management of hypertension-related issues.