肝移植患者移植前融合评分与30天和60天死亡率的相关性

Faryal Riaz Khan, Rao Saad Ali Khan, Khawar Shabbir, Asim Shehzad, Fuad Ahmad Siddiqi, Zara Riaz Khan, Muhammad Bilal Khattak
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引用次数: 0

摘要

背景:终末期肝病(MELD)评分模型是由器官共享联合网络(UNOS)于2002年引入的,是预测肝移植候选人死亡率的重要工具。MELD评分包括血清肌酐、血清胆红素和国际标准化比值(INR),包括肾脏、肝脏和凝血途径功能,提供了一个全面的预后工具。最近的研究提出了更广泛的预后影响,超出了器官分配。尽管它有好处,但大约15-20%的患者可能无法准确预测生存。方法:本回顾性单中心研究涵盖2016年1月至2023年9月87例患者,探讨移植前MELD评分与移植后30至60天生存率的相关性。结果:我们的分析显示,MELD评分对这一时期的生存率没有显著影响,挑战了现有文献(p=0.068)。该研究强调了在MELD评分之外进行细致入微的风险评估的必要性,考虑到不同的临床情况和患者特定的变量。结论:我们的发现有助于完善预测模型,提倡更大规模的研究,强调整体方法来优化肝移植结果。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
CORRELATION OF PRE-TRANSPLANT MELD SCORE WITH 30- AND 60-DAYS' MORTALITY IN PATIENTS OF LIVER TRANSPLANT.

Background: The Model for End-Stage Liver Disease (MELD) score, introduced in 2002 by the United Network for Organ Sharing (UNOS), is a vital tool for predicting mortality for liver transplant candidates. Comprising serum creatinine, serum bilirubin, and international normalized ratio (INR), the MELD score includes kidney, liver, and coagulation pathway function, providing a comprehensive prognostic tool. Recent studies suggest broader prognostic implications, extending beyond organ allocation. Despite its benefits, around 15-20% of patients may not experience accurate survival predictions.

Methods: This retrospective single-center study, covering January 2016 to September 2023 with 87 patients, explores the correlation between pre-transplant MELD scores and 30 to 60-day post-transplant survival.

Results: Our analysis reveals no significant impact of MELD scores on survival during this period, challenging existing literature (p=0.068). The study underscores the need for nuanced risk assessment beyond MELD scores, considering diverse clinical scenarios and patient-specific variables.

Conclusions: Our findings contribute to refining predictive models and advocate for larger-scale investigations, emphasizing a holistic approach to optimize liver transplantation outcomes.

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