【脊椎关节炎发病机制中的微生物和遗传因素】。

IF 0.9 4区医学 Q4 RHEUMATOLOGY

Zeitschrift fur Rheumatologie Pub Date : 2024-12-02 DOI:10.1007/s00393-024-01593-w

Judith Rademacher, Denis Poddubnyy, Valeria Rios Rodriguez

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引用次数: 0

摘要

脊椎关节炎（SpA）是一种异质性的疾病，其确切的发病机制尚不清楚。遗传易感性（主要是HLA-B*27阳性）、屏障渗漏（皮肤和肠道）和环境影响（如接触某些微生物群）之间的相互作用被怀疑会导致免疫系统的激活，并通过这种方式导致疾病的发展和维持。

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[Microbial and genetic factors in the pathogenesis of spondyloarthritis].

Spondyloarthritis (SpA) is a heterogenous group of diseases with an yet unknown exact pathogenesis. An interplay between genetic predispositionw (mainly HLA-B*27 positivity), a barrier leakage (of skin and gut) and environmental influences, such as the contact to certain microbiota are suspected to lead to an activation of the immune system and through this to the development and maintenance of the disease.

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来源期刊

Zeitschrift fur Rheumatologie 医学-风湿病学

CiteScore

2.20

自引率

20.00%

发文量

150

审稿时长

6-12 weeks

期刊介绍： Die Zeitschrift für Rheumatologie ist ein international angesehenes Publikationsorgan und dient der Fortbildung von niedergelassenen und in der Klinik tätigen Rheumatologen. Die Zeitschrift widmet sich allen Aspekten der klinischen Rheumatologie, der Therapie rheumatischer Erkrankungen sowie der rheumatologischen Grundlagenforschung. Umfassende Übersichtsarbeiten zu einem aktuellen Schwerpunktthema sind das Kernstück jeder Ausgabe. Im Mittelpunkt steht dabei gesichertes Wissen zu Diagnostik und Therapie mit hoher Relevanz für die tägliche Arbeit – der Leser erhält konkrete Handlungsempfehlungen. Frei eingereichte Originalien ermöglichen die Präsentation wichtiger klinischer Studien und dienen dem wissenschaftlichen Austausch.