山羊球虫病肠细胞热休克蛋白70活性的研究。

IF 1.6 4区生物学 Q4 BIOTECHNOLOGY & APPLIED MICROBIOLOGY

Biotechnic & Histochemistry Pub Date : 2024-11-01 Epub Date: 2024-12-04 DOI:10.1080/10520295.2024.2427790

Mehmet Hesapçıoğlu, Hamdi Avcı

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引用次数: 0

摘要

球虫病是山羊养殖中最常见的传染病之一。这种疾病在世界上造成了重大的经济损失。在本研究中，我们旨在研究热休克蛋白70在球虫病山羊肠细胞中的活性。为此，我们总共使用了27只山羊。主要表现为腹泻、恶病质和脱水。在显微镜检查中，我们观察到增殖性肠炎伴艾美耳球虫。寄生虫。免疫组化检查显示肠道中至重度Hsp70免疫反应。考虑到Hsp70是一种具有抗凋亡和免疫调节功能的应激蛋白，Hsp70的免疫反应性归因于感染引起的应激和蛋白的抗凋亡活性以及Hsp70的免疫调节作用。

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Investigation of the heat shock protein 70 activity in intestine cells of goats with coccidiosis.

Coccidiosis is one of the most common infectious diseases in goat farming. The disease causes major economic loss in the world. In this study, we aimed to investigate the activity of heat shock protein 70 in intestine cells of goats with coccidiosis. We used total of twenty-seven goats for this purpose. Gross findings were diarrhoea, cachexia, and dehydration. In the microscopical examination, we observed proliferative enteritis with Eimeria. parasites. Immunohistochemical examinations revealed moderate to severe Hsp70 immunoreactivity in intestines. Considering Hsp70 is a stress protein with anti-apoptotic and immune regulatory features, Hsp70 immunoreactivity attributed to the stress caused by infection and anti-apoptotic activity of the protein along with immune regulatory effects of Hsp70.

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来源期刊

Biotechnic & Histochemistry 生物-生物工程与应用微生物

CiteScore

3.40

自引率

6.20%

发文量

审稿时长

6-12 weeks

期刊介绍： Biotechnic & Histochemistry (formerly Stain technology) is the official publication of the Biological Stain Commission. The journal has been in continuous publication since 1926. Biotechnic & Histochemistry is an interdisciplinary journal that embraces all aspects of techniques for visualizing biological processes and entities in cells, tissues and organisms; papers that describe experimental work that employs such investigative methods are appropriate for publication as well. Papers concerning topics as diverse as applications of histochemistry, immunohistochemistry, in situ hybridization, cytochemical probes, autoradiography, light and electron microscopy, tissue culture, in vivo and in vitro studies, image analysis, cytogenetics, automation or computerization of investigative procedures and other investigative approaches are appropriate for publication regardless of their length. Letters to the Editor and review articles concerning topics of special and current interest also are welcome.