嵌合抗原受体-自然杀伤细胞免疫治疗癌症的进展与挑战。

IF 5.1 2区医学 Q1 HEMATOLOGY

British Journal of Haematology Pub Date : 2024-12-02 DOI:10.1111/bjh.19939

Hind Rafei, Katayoun Rezvani

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引用次数: 0

摘要

嵌合抗原受体(CAR)-自然杀伤细胞(NK)-细胞疗法已成为治疗血液系统恶性肿瘤和实体癌的一种有前途的策略。利用NK细胞的先天免疫特性，car -NK细胞疗法为细胞疗法提供了潜在的优势，包括在异体环境中使用的安全性和降低毒性风险。本文概述了car - nk细胞治疗的最新进展和仍然存在的挑战。

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Advances and challenges in chimeric antigen receptor-natural killer cell immunotherapy for cancer.

Chimeric antigen receptor (CAR)-natural killer (NK)-cell therapy has emerged as a promising strategy in the treatment of haematological malignancies and solid cancers. Leveraging the innate immune properties of NK cells, CAR-NK-cell therapies offer potential advantages for cell therapy, including safety of use in the allogeneic setting and reduced risk of toxicity. This Nutshell provides an overview of the latest advancements in CAR-NK-cell therapy and the challenges that remain.

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来源期刊

British Journal of Haematology 医学-血液学

CiteScore

8.60

自引率

4.60%

发文量

565

审稿时长

1 months

期刊介绍： The British Journal of Haematology publishes original research papers in clinical, laboratory and experimental haematology. The Journal also features annotations, reviews, short reports, images in haematology and Letters to the Editor.