布瑟林和氨酰硫胺完全阻断雌激素治疗晚期乳腺癌:一项长期激素相关性的I-II期研究

Chemioterapia : international journal of the Mediterranean Society of Chemotherapy Pub Date : 1988-12-01

V Ferrari, A Zaniboni, E Simoncini, E Marpicati, E Montini, R Moretti, G Marini

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引用次数: 0

摘要

我们对21例晚期乳腺癌患者应用布西林、氨酰硫胺和醋酸可的松治疗，试图在绝经前和绝经后患者中获得完全的雌激素阻断。10例患者(47%)获得客观缓解，无相关副作用。在处理激素数据时，必须概述的是，绝经后患者的血清睾酮水平显著下降，这可能解释了这组患者中黄体生成素释放激素类似物的活性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Complete estrogen blockade with buserelin and aminoglutethimide for advanced breast cancer: a phase I-II study with long-term hormonal correlations.

We treated 21 patients with advanced breast cancer with buserelin, aminoglutethimide and cortisone acetate in an attempt to obtain a complete estrogen blockade both in premenopausal and postmenopausal patients. Ten patients (47%) obtained an objective response without any relevant side-effects. Dealing with hormonal data, it must be outlined that serum testosterone levels decreased significantly in postmenopausal patients, suggesting a possible explanation for the activity of luteinizing hormone-releasing hormone analogue in this group of patients.

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Chemioterapia : international journal of the Mediterranean Society of Chemotherapy

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