平行共同靶向识别癌症类型的选择性基因冗余

IF 29.7 1区医学 Q1 ONCOLOGY

Cancer discovery Pub Date : 2024-12-02 DOI:10.1158/2159-8290.cd-24-1349

Gregory Gauthier-Coles, Jason M. Sheltzer

引用次数: 0

摘要

摘要：在这期研究中，Klingbeil及其同事采用平行共靶向策略揭示了微管亲和调节激酶2和3是Hippo通路的冗余负调控因子，也是YAP/ taz成瘾肿瘤中潜在的可操作靶点。参见克林贝尔等人的相关文章。，第2471页

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Paralog Co-Targeting Identifies Selective Genetic Redundancies across Cancer Types

Summary:In this issue, Klingbeil and colleagues deploy a paralog co-targeting strategy to reveal microtubule affinity–regulating kinases 2 and 3 as redundant negative regulators of the Hippo pathway and potentially actionable targets in YAP/TAZ-addicted tumors.See related article by Klingbeil et.al., p. 2471

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来源期刊

Cancer discovery ONCOLOGY-

CiteScore

22.90

自引率

1.40%

发文量

838

审稿时长

6-12 weeks

期刊介绍： Cancer Discovery publishes high-impact, peer-reviewed articles detailing significant advances in both research and clinical trials. Serving as a premier cancer information resource, the journal also features Review Articles, Perspectives, Commentaries, News stories, and Research Watch summaries to keep readers abreast of the latest findings in the field. Covering a wide range of topics, from laboratory research to clinical trials and epidemiologic studies, Cancer Discovery spans the entire spectrum of cancer research and medicine.