cs2co3催化多组分一锅分步法合成2-聚取代吡啶酮

IF 2 4区 化学 Q3 CHEMISTRY, MULTIDISCIPLINARY
Shitao Liu, Chixian He, Guijun Li, Yanling Xu, Xianfu Shen, Teng Liu
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引用次数: 0

摘要

提出了一种简单可行的以Cs2CO3为催化剂的四组分一锅步进环化法合成多取代2-吡啶酮的方法。在这个逐步转化过程中,通过分子间缩合/aza-Michael反应/分子间Michael加成/分子内环化,生成了两个新的C-C键和两个新的C-N键。替代方案提供了一个互补的途径,在温和的条件下,从容易获得的原料芳胺、二烷基乙炔二羧酸酯、1,3-二羰基化合物和原甲酸三烷基酯中获得一系列结构多样的多取代2-吡啶酮(21个例子),收率从良好到优异(52-81%)。这可能为发现含2-吡啶的药物提供新的机会。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Cs2CO3-Catalyzed Multi-Component One-Pot Stepwise Route for the Synthesis of Polysubstituted 2-Pyridones

Cs2CO3-Catalyzed Multi-Component One-Pot Stepwise Route for the Synthesis of Polysubstituted 2-Pyridones

Cs2CO3-Catalyzed Multi-Component One-Pot Stepwise Route for the Synthesis of Polysubstituted 2-Pyridones

A concise and practicable route to the synthesis of multisubstituted 2-pyridones via a four-component one-pot stepwise cyclization catalyzed by Cs2CO3 has been developed. During this stepwise transformation, two new C-C bonds and two new C-N bonds were generated through an intermolecular condensation/aza-Michael reaction/intermolecular Michael addition/intramolecular cyclization sequence. The alternative protocol offers a complementary route to provide a series of structurally diverse polysubstituted 2-pyridones (21 examples) in good to excellent yields (52–81%) from easily available raw materials arylamines, dialkyl acetylenedicarboxylate, 1,3-dicarbonyl compounds, and trialkyl orthoformate under mild conditions. It might provide new opportunities for the discovery of 2-pyridones-containing drugs.

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来源期刊
ChemistrySelect
ChemistrySelect Chemistry-General Chemistry
CiteScore
3.30
自引率
4.80%
发文量
1809
审稿时长
1.6 months
期刊介绍: ChemistrySelect is the latest journal from ChemPubSoc Europe and Wiley-VCH. It offers researchers a quality society-owned journal in which to publish their work in all areas of chemistry. Manuscripts are evaluated by active researchers to ensure they add meaningfully to the scientific literature, and those accepted are processed quickly to ensure rapid online publication.
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