Nuplon:可在水中完全降解的新型合成聚合物。

IF 10.5 1区 医学 Q1 CHEMISTRY, MULTIDISCIPLINARY
John Garner , Kinam Park
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引用次数: 0

摘要

新型交联聚酯是通过多羟基醇(如季戊四醇或甘油)、多羧酸(如柠檬酸)和羟基酸化合物(如乳酸)的直接聚酯合成的,这种交联聚酯在水的存在下可以在环境中完全降解几个月。该反应产生的交联基质具有固体机械性能,在环境中可降解。该反应可以在中热(100-200 °C)下进行,不需要额外的催化剂、惰性气体或真空的帮助。交联的基体可以是热塑性或热固性的,这取决于交联的程度,这是由反应时间和温度控制。不同比例的单体形成的聚酯在95 °C下在水中降解12 h, 70 °C下降解3 天,30 °C下降解约3 个月。这些环境可降解的烷基聚酯包括一系列的机械强度和弹性,使它们适用于各种应用。这些环境可降解的合成聚合物可以在各种应用中取代目前不可降解的聚合物。这些新的聚合物被命名为“Nuplons”。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Nuplon: New synthetic polymers fully degradable in water

Nuplon: New synthetic polymers fully degradable in water
New crosslinked polyesters, which are fully degradable in the presence of water over several months in the environment, were synthesized by direct polyesterification of multi-hydroxylic alcohols (e.g., pentaerythritol or glycerol), multi-carboxylic acids (e.g., citric acid), and hydroxy acid compounds (e.g., lactic acid). The reaction produced a crosslinked matrix with mechanical properties of solid and useful degradability in the environment. This reaction can be performed with moderate heat (100–200 °C) and without requiring the aid of additional catalysts, inert gas, or vacuum. The crosslinked matrix can be thermoplastic or thermoset, depending on the extent of crosslinking, which is controlled by reaction time and temperature. The polyesters formed with various ratios of the monomers degrade in water in 12 h at 95 °C, 3 days at 70 °C, and about 3 months at 30 °C. These environmentally degradable alkyl polyesters include a range of mechanical strengths and elasticity, making them suitable for various applications. These environmentally degradable, synthetic polymers can replace current non-degradable polymers in various applications. These new polymers are named “Nuplons”.
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来源期刊
Journal of Controlled Release
Journal of Controlled Release 医学-化学综合
CiteScore
18.50
自引率
5.60%
发文量
700
审稿时长
39 days
期刊介绍: The Journal of Controlled Release (JCR) proudly serves as the Official Journal of the Controlled Release Society and the Japan Society of Drug Delivery System. Dedicated to the broad field of delivery science and technology, JCR publishes high-quality research articles covering drug delivery systems and all facets of formulations. This includes the physicochemical and biological properties of drugs, design and characterization of dosage forms, release mechanisms, in vivo testing, and formulation research and development across pharmaceutical, diagnostic, agricultural, environmental, cosmetic, and food industries. Priority is given to manuscripts that contribute to the fundamental understanding of principles or demonstrate the advantages of novel technologies in terms of safety and efficacy over current clinical standards. JCR strives to be a leading platform for advancements in delivery science and technology.
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