Ag@polydopamine-functionalized硼酸酯连接壳聚糖水凝胶集成监测伤口愈合表皮传感器

IF 12.3 1区材料科学 Q1 ENGINEERING, ELECTRICAL & ELECTRONIC

npj Flexible Electronics Pub Date : 2024-11-30 DOI:10.1038/s41528-024-00366-4

Wei Shi, Hui Li, Chengsheng Xu, Gaoyi Wu, Jing Chen, Jinyong Zhang, Lixin Liang, Qingyang Wu, Yongsheng Liang, Guanglin Li, Wei Tang

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引用次数: 0

摘要

柔性传感器是个性化医疗保健中很有前途的候选者，而允许植入具有最佳传感和有利生物特性的生物医学应用的传感器仍然是挑战。本文以没食子酸修饰壳聚糖（CSGA）和3-羧基苯基硼酸修饰壳聚糖（CSPBA）为材料，包封ag修饰的聚多巴胺（Ag@PDA）纳米粒子Ag@PDA-(CSPBA/CSGA)，制备了多功能水凝胶传感器。优化后的水凝胶传感器具有理想的灵敏度（测量因子= 2.49）、263 ms的快速响应/恢复时间和良好的耐用性。由于Ag@PDA-(CSPBA/CSGA)中存在丰富的反应基团，该水凝胶传感器对大肠杆菌（92.76%）和金黄色葡萄球菌（98.08%）具有自愈、组织粘附、抗氧化和抗菌等综合性能。此外，水凝胶传感器可以用作伤口敷料，促进伤口愈合和组织再生。水凝胶传感器可以监测和区分细微的活动和大规模的运动。该研究提供了一种具有多种功能的表皮传感器，可用于健康监测和伤口管理。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Ag@polydopamine-functionalized borate ester-linked chitosan hydrogel integrates monitoring with wound healing for epidermal sensor

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Ag@polydopamine-functionalized borate ester-linked chitosan hydrogel integrates monitoring with wound healing for epidermal sensor

Flexible sensors are promising candidates in personalized healthcare, while desired sensors that allow implantation for biomedical applications with optimal sensing and favorable biological properties remain challenges. Here, a multifunctional hydrogel sensor was developed with gallic acid-modified chitosan (CSGA) and 3-carboxyphenylboronic acid-modified chitosan (CSPBA) by encapsulating Ag-decorated polydopamine (Ag@PDA) nanoparticles, namely Ag@PDA-(CSPBA/CSGA). The optimized hydrogel sensor showed desired sensitivity (gauge factor = 2.49), a rapid response/recovery time of 263 ms and good durability. Due to the presence of abundant reactive groups within Ag@PDA-(CSPBA/CSGA), the hydrogel sensor exhibited a comprehensive performance of self-healing, tissue adhesiveness, antioxidative activity, and antibacterial effects against Escherichia coli (92.76%) and Staphylococcus aureus (98.08%). Moreover, the hydrogel sensor could be utilized as a wound dressing, facilitating accelerated wound closure and tissue regeneration. Both subtle activities and large-scale movements could be monitored and distinguished by the hydrogel sensor. This study provides a promising epidermal sensor that offers multifunctionality for health monitoring and wound management.

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来源期刊

npj Flexible Electronics Multiple-

CiteScore

17.10

自引率

4.80%

发文量

审稿时长

6 weeks

期刊介绍： npj Flexible Electronics is an online-only and open access journal, which publishes high-quality papers related to flexible electronic systems, including plastic electronics and emerging materials, new device design and fabrication technologies, and applications.